Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development

Active, not recruiting

• Conditions: Gestational Diabetes; Insulin Resistance; Obesity Prevention

• Registration Number: NCT01623934
• Lead Sponsor: Université de Sherbrooke

Brief Summary

This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3, 5 and 10-12 year after delivery.

The purpose of this phase 1 is to :

* assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes;

* assess levels of maternal adipokines as determinants of development and fetal growth;

* determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns.

The purpose of this phase 2 is to:

* identify DNA methylation variations at birth that are predictive of childhood overweight/obesity.

* identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity.

* establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age).

* identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3, 5 and 10 years of age.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2012-06-18
• Study First Submitted QC: 2012-06-18
• Study First Posted: 2012-06-20
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-16
• Last Update Posted: 2024-10-18
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Female
• Target Recruitment: 1034

Inclusion Criteria

• age ≥ 18 yrs
• gestational age between 6 and 13 weeks from last menstrual period
• no recognized diabetes or drugs interfering with glucose metabolism
• alcohol < 2 drinks/day
• not involved in regular high intensity physical activity
• otherwise good health status

Exclusion Criteria

• twin pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis of gestational diabetes mellitus	24-28 weeks of gestation	75g oral glucose tolerance test

Trial Locations

Locations (1)

Centre de recherche du Centre hospitalier universitaire de Sherbrooke; 🇨🇦 Sherbrooke, Quebec, Canada