Glucose Metabolism in Pregnant Women With a History of Bariatric Surgery, as Well as Three to Six Months After Delivery.
- Conditions
- Bariatric Surgery CandidatePregnancy ComplicationsGlucose Metabolism DisordersPregnancy Related
- Interventions
- Other: OGTTOther: IVGTTOther: 1H-magnetic resonance spectroscopy
- Registration Number
- NCT03190148
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
In this study glucose metabolism of pregnant women with a history of bariatric surgery, obese pregnant women and normal weight pregnant women was investigated. Three to six months after delivery the assessment of Glucose metabolism was repeated and the amount of ectopic lipids in the liver, heart and muscle was measured.
- Detailed Description
In this study pregnant women with a history of bariatric surgery, normal weight and obese pregnant women were invited to participate. Between the 24th and the 28th week of pregnancy an oral glucose tolerance test (OGTT), as well as an intravenous glucose tolerance test (IVGTT) was conducted. Three to six months after delivery the examinations were repeated. In addition the ectopic lipid content in the liver, heart and the muscle was measured with 1H-magnetic resonance spectroscopy and imaging three to six months post partum. The aim of this study was to compare the glucose metabolism during pregnancy between the three groups as well as to investigate the changes three to six months after delivery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 64
- pregnant women with a history of RYGB Operation
- normal weight pregnant women
- obese pregnant women
- infectious diseases such as Hepatitis B or C, HIV, hematological diseases, acute infections, liver disease, renal disease, cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Obese Pregnant women OGTT Obese pregnant women were investigated. Normal weight pregnant women OGTT Normal weight pregnant women were investigated. Pregnant women with RYGB-operation 1H-magnetic resonance spectroscopy Pregnant women with a history of RYGB-Operation were investigated. Normal weight pregnant women IVGTT Normal weight pregnant women were investigated. Obese Pregnant women 1H-magnetic resonance spectroscopy Obese pregnant women were investigated. Pregnant women with RYGB-operation IVGTT Pregnant women with a history of RYGB-Operation were investigated. Normal weight pregnant women 1H-magnetic resonance spectroscopy Normal weight pregnant women were investigated. Obese Pregnant women IVGTT Obese pregnant women were investigated. Pregnant women with RYGB-operation OGTT Pregnant women with a history of RYGB-Operation were investigated.
- Primary Outcome Measures
Name Time Method Assessment of glucose metabolism using an oral Glucose tolerance test (OGTT) and an intravenous Glucose tolerance test (IVGTT) in pregnant women with a history of bariatric surgery, as well as three to six months after delivery up to 10 months In this study the Glucose metabolism (including beta cell function, Insulin resistance and Insulin secretion) of pregnant women with a history of bariatric surgery was investigated with an OGTT and an IVGTT between the 24th and the 28th week of pregnancy. In Detail a measurement of the dynamic changes of Glucose, glucagon, C-peptide, Insulin and GLP-1 Levels during the OGTT and the IVGTT in pregnant women with a history of bariatric surgery was done. Three to six months after delivery the OGTT and the IVGTT were repeated and a 1H-magnetic resonance spectroscopy for the measurement of the amount of ectopic lipids in the liver, heart and the muscle was done.
- Secondary Outcome Measures
Name Time Method