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Glucose Metabolism in Pregnant Women With a History of Bariatric Surgery, as Well as Three to Six Months After Delivery.

Not Applicable
Completed
Conditions
Bariatric Surgery Candidate
Pregnancy Complications
Glucose Metabolism Disorders
Pregnancy Related
Interventions
Other: OGTT
Other: IVGTT
Other: 1H-magnetic resonance spectroscopy
Registration Number
NCT03190148
Lead Sponsor
Medical University of Vienna
Brief Summary

In this study glucose metabolism of pregnant women with a history of bariatric surgery, obese pregnant women and normal weight pregnant women was investigated. Three to six months after delivery the assessment of Glucose metabolism was repeated and the amount of ectopic lipids in the liver, heart and muscle was measured.

Detailed Description

In this study pregnant women with a history of bariatric surgery, normal weight and obese pregnant women were invited to participate. Between the 24th and the 28th week of pregnancy an oral glucose tolerance test (OGTT), as well as an intravenous glucose tolerance test (IVGTT) was conducted. Three to six months after delivery the examinations were repeated. In addition the ectopic lipid content in the liver, heart and the muscle was measured with 1H-magnetic resonance spectroscopy and imaging three to six months post partum. The aim of this study was to compare the glucose metabolism during pregnancy between the three groups as well as to investigate the changes three to six months after delivery.

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
64
Inclusion Criteria
  • pregnant women with a history of RYGB Operation
  • normal weight pregnant women
  • obese pregnant women
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Exclusion Criteria
  • infectious diseases such as Hepatitis B or C, HIV, hematological diseases, acute infections, liver disease, renal disease, cancer
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Obese Pregnant womenOGTTObese pregnant women were investigated.
Normal weight pregnant womenOGTTNormal weight pregnant women were investigated.
Pregnant women with RYGB-operation1H-magnetic resonance spectroscopyPregnant women with a history of RYGB-Operation were investigated.
Normal weight pregnant womenIVGTTNormal weight pregnant women were investigated.
Obese Pregnant women1H-magnetic resonance spectroscopyObese pregnant women were investigated.
Pregnant women with RYGB-operationIVGTTPregnant women with a history of RYGB-Operation were investigated.
Normal weight pregnant women1H-magnetic resonance spectroscopyNormal weight pregnant women were investigated.
Obese Pregnant womenIVGTTObese pregnant women were investigated.
Pregnant women with RYGB-operationOGTTPregnant women with a history of RYGB-Operation were investigated.
Primary Outcome Measures
NameTimeMethod
Assessment of glucose metabolism using an oral Glucose tolerance test (OGTT) and an intravenous Glucose tolerance test (IVGTT) in pregnant women with a history of bariatric surgery, as well as three to six months after deliveryup to 10 months

In this study the Glucose metabolism (including beta cell function, Insulin resistance and Insulin secretion) of pregnant women with a history of bariatric surgery was investigated with an OGTT and an IVGTT between the 24th and the 28th week of pregnancy. In Detail a measurement of the dynamic changes of Glucose, glucagon, C-peptide, Insulin and GLP-1 Levels during the OGTT and the IVGTT in pregnant women with a history of bariatric surgery was done. Three to six months after delivery the OGTT and the IVGTT were repeated and a 1H-magnetic resonance spectroscopy for the measurement of the amount of ectopic lipids in the liver, heart and the muscle was done.

Secondary Outcome Measures
NameTimeMethod
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