Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis

• Conditions: Microsporidial Keratoconjunctivitis

• Registration Number: NCT03555409
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis.

Detailed Description

Microsporidia comprise a diverse group of obligate spore-forming intracellular eukaryotic pathogens first described in immunocompromised patients. Many species of microsporidia are found in aquatic environments, and they are considered as waterborne pathogens.Microsporidia are opportunistic pathogens that are reported to cause infections in various organs, including the eyes. The ocular appearance of this infection can manifest as corneal stromal keratitis or a superficial punctate keratoconjunctivitis. In particular, the characteristic feature of microsporidial keratoconjunctivitis is multiple whitish, slightly elevated epithelial lesions in conjunction with acute conjunctivitis. Awareness of microsporidial keratoconjunctivitis is increasing, and the number of cases reported is on the rise. This study was a retrospective case series of patients diagnosed as microsporidial keratoconjunctivitis. The purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis

Study Timeline

• Status Verified: 2018-05
• Study Start: 2018-06-01
• Study First Submitted: 2018-06-01
• Study First Submitted QC: 2018-06-01
• Study First Posted: 2018-06-13
• Last Update Submitted: 2018-06-13
• Last Update Posted: 2018-06-15
• Primary Completion: 2019-05-31
• Study Completion: 2019-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients diagnosed as microsporidial keratoconjunctivitis

Exclusion Criteria

• Patients diagnosed as bacterial or viral keratoconjunctivitis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Full chart records of the patients who diagnosed as microsporidial keratoconjunctivitis	2018/6/1-2019/5/31	Charts of all patients diagnosed as microsporidial keratoconjunctivitis between January, 2008 and April, 2018 at National Taiwan University Hospital were reviewed.

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan