The Effects of Bariatric Surgery on Impulsivity and Attentional Bias to Food Cues
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Change in background activity in the brain (resting state activity) after bariatric surgery
研究概览
简要总结
After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (~ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate.
This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.
详细描述
We will also investigate whether hormonal changes in response to food intake after obesity surgery is associated with patients' impulsive control when exposed to pictures of food in the MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •right-handed
- •scheduled for bariatric surgery in the Academic Hospital of Uppsala, Sweden
排除标准
- •undergone more than one bariatric surgery
- •suffer from mental disorders (depression, phobias, etc.) that can not be controlled with treatment.
结局指标
主要结局
Change in background activity in the brain (resting state activity) after bariatric surgery
时间窗: 1 year
Brain's basic activity and structure will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using fMRI.
次要结局
- Change in response inhibition after bariatric surgery(1 year)