Cross Sectional Observation Study of Cough Dysfunction in Infratentorial Brain Lesion Patients, as Assessed by M-mode Sonography
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Diaphragm excursion
研究概览
简要总结
To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university affiliated rehabilitation department.
详细描述
Our previous work has shown that stroke patients with dysphagia have impaired diaphragm excursion in comparison to those with no dysphagia. It has been postulated that respiratory and cough function are primarily controlled by respiratory and swallowing centers located in the brainstem.We postulated that those with infratentorial brain lesions would have more impaired cough and respiratory function than those with non-brainstem lesions and supratentorial brain lesions.
However there has been no studies whether those with infratentorial brain lesions have more impaired cough function and decreased diaphragm excursion than those with supratentorial brain lesions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Group 1- Brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube Group 2- Non-brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube Group 3- Stroke patients with no evidence of dysphagia
排除标准
- •Episode of acute pneumonia or pulmonary embolism at time of enrollment
- •Previous history of chronic respiratory disorders or other systemic disorders that may affect respiratory function ( ex, rheumatoid arthritis, chronic renal disease, spinal cord injury)
- •Stroke patients with multiple brain lesions
- •Episode of Diaphragm weakness due to peripheral polyneuropathy or unilateral phrenic nerve palsy
- •Previous episode of abdominal or thoracic surgery within one year of enrollment
- •Concomitant diagnosis of myopathy, muscular dystrophy or other disorders that may affect respiratory muscles.
- •Episode of rib fracture within one year of enrollment
- •Chronic alcoholism
- •Patient with previous diagnosis of dementia or with impaired cognitive function that may limit full participation at the evaluation
- •Patient with tracheostomy state
结局指标
主要结局
Diaphragm excursion
时间窗: baseline one time
Diaphragm excursion as assessed by m mode sonography
次要结局
- Maximal inspiratory pressure(baseline one time)
- Peak cough flow force during voluntary coughing(baseline one time)
研究者
Sun Im
Assistant Professor
The Catholic University of Korea