Coughing in Infratentorial Brain Lesion Patients

Completed

• Conditions: Stroke
• Interventions: Other: Not applicable (observational study with no active intervention)

• Registration Number: NCT02081040
• Lead Sponsor: The Catholic University of Korea

Brief Summary

To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university affiliated rehabilitation department.

Detailed Description

Our previous work has shown that stroke patients with dysphagia have impaired diaphragm excursion in comparison to those with no dysphagia. It has been postulated that respiratory and cough function are primarily controlled by respiratory and swallowing centers located in the brainstem.We postulated that those with infratentorial brain lesions would have more impaired cough and respiratory function than those with non-brainstem lesions and supratentorial brain lesions.

However there has been no studies whether those with infratentorial brain lesions have more impaired cough function and decreased diaphragm excursion than those with supratentorial brain lesions.

Study Timeline

• Study Start: 2013-09
• Study First Submitted: 2014-03-04
• Study First Submitted QC: 2014-03-05
• Study First Posted: 2014-03-07
• Primary Completion: 2014-06
• Study Completion: 2014-08
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-22
• Last Update Posted: 2015-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Group 1- Brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube Group 2- Non-brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube Group 3- Stroke patients with no evidence of dysphagia

Exclusion Criteria

• Episode of acute pneumonia or pulmonary embolism at time of enrollment
• Previous history of chronic respiratory disorders or other systemic disorders that may affect respiratory function ( ex, rheumatoid arthritis, chronic renal disease, spinal cord injury)
• Stroke patients with multiple brain lesions
• Episode of Diaphragm weakness due to peripheral polyneuropathy or unilateral phrenic nerve palsy
• Previous episode of abdominal or thoracic surgery within one year of enrollment
• Concomitant diagnosis of myopathy, muscular dystrophy or other disorders that may affect respiratory muscles.
• Episode of rib fracture within one year of enrollment
• Chronic alcoholism
• Patient with previous diagnosis of dementia or with impaired cognitive function that may limit full participation at the evaluation
• Patient with tracheostomy state

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Brain lesion patients without dysphagia	Not applicable (observational study with no active intervention)	Brain lesion patients with no evidence of dysphagia

Primary Outcome Measures

Name	Time	Method
Diaphragm excursion	baseline one time	Diaphragm excursion as assessed by m mode sonography

Secondary Outcome Measures

Name	Time	Method
Maximal inspiratory pressure	baseline one time
Peak cough flow force during voluntary coughing	baseline one time

Trial Locations

Locations (1)

Bucheon St Mary's Hospital; 🇰🇷 Bucheon, Gyonngido, Korea, Republic of