The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture

Not Applicable

• Conditions: Ankle Fracture
• Interventions: Dietary Supplement: vitamin c; Drug: placebo

• Registration Number: NCT01338129
• Lead Sponsor: Rabin Medical Center

Brief Summary

The use of prophylactic treatment with vitamin c may prevent complex regional pain syndrome (CRPS)

Detailed Description

There are several studies similar in wrist fracture.

Study Timeline

• Status Verified: 2011-03
• Study First Submitted: 2011-03-28
• Study Start: 2011-04
• Study First Submitted QC: 2011-04-18
• Last Update Submitted: 2011-04-18
• Study First Posted: 2011-04-19
• Last Update Posted: 2011-04-19
• Primary Completion: 2013-12
• Study Completion: 2014-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• ankle fracture within 3 weeks after the fracture

Exclusion Criteria

• pregnant or lactating woman
• open fracture
• already treated with vitamin c
• chronic renal failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
vitamin c	vitamin c	administration of vitamin c for 45 days following ankle fracture operation
placebo	placebo	placebo pills

Primary Outcome Measures

Name	Time	Method
CRPS incidence	6 months	the incidence of CRPS (according to the IASP or Bruehl diagnostic cruteria) in both population following the fracture will be record and compared

Trial Locations

Locations (1)

Beilinson, Rabin Medical Center,; 🇮🇱 Petah Tikva,, Israel