Does vitamin C decrease post-operative pain in surgery to the foot and ankle?

Not Applicable

• Conditions: Complex Regional Pain Syndrome; Patients who have foot and ankle pathology (such as fracture, arthritis and ligament injuries) who require surgical treatment to treat the pathology.; Musculoskeletal - Other muscular and skeletal disorders; Surgery - Other surgery; Injuries and Accidents - Fractures; Injuries and Accidents - Other injuries and accidents; Anaesthesiology - Pain management; Neurological - Other neurological disorders

• Registration Number: ACTRN12621000812897
• Lead Sponsor: Frankston Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-06-28
• Last Update Posted: 5 July 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

•Patients need to be aged 18 and over to participate in the trial. This is because most fractures in the lower limb in children are treated non-operatively. In addition, most sites have limited numbers of younger patients who have surgery for foot or ankle problems, recruitment of people under the age of 18 is unfeasible.
•Patients need to be able to provide informed consent for the trial via a signed and dated consent form. Patients who are unable to provide informed consent because of (for example) cognitive impairment will be excluded.
•Patients who present to Peninsula Health, Frankston Private Hospital, Holmesglen Private Hospital, Beleura Private Hospital or Cabrini Brighton Private Hospital for surgery of the foot and ankle, either elective or emergency, will be eligible to participate.

Exclusion Criteria

•Current or recent (ie less than three months prior to randomization) use of vitamin C, either as an isolated substance or as part of a multi-vitamin tablet. This is because the vitamin C dosing will not be standardized if patients are also taking the vitamin, and there is potential for overdosing. Vitamin C has a half-life of 10-20 days and therefore a long exclusion period is required.
•Patients who are pregnant or breastfeeding will be excluded due to the unknown safety risks in this patient population.
•Patients who are unable to commence taking the placebo/vitamin C medication within 72 hours after their surgery will be excluded from the trial
•Patients unable or unwilling to take oral medications.
•Patients who are vegan (as the placebo acidophilus is dairy based)

Study & Design

• Study Type: Interventional
• Study Design: Not specified