Direct Measurement of Motor Cortical Responses to tDCS
- Conditions
- Parkinson DiseaseChronic Stroke
- Interventions
- Device: transcranial direct current stimulation (noninvasive recording)Device: sham transcranial direct current stimulation (noninvasive recording)Device: transcranial direct current stimulation (invasive recording)
- Registration Number
- NCT04759898
- Lead Sponsor
- Medical University of South Carolina
- Brief Summary
Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. The investigators hypothesize that by studying the effects of tDCS in subjects performing a motor task, the brain signals mediating improvements in motor control will be identified. The investigators will use both noninvasive and invasive methods to explore this hypothesis. The investigators expect this combined approach to broaden understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in these populations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 80
- Age 18 or older
- Previous consent to be contacted regarding potential participation in a research study at Medical University of South Carolina
- Subjects unable to actively participate in the consent process physically and/or cognitively
- Pregnancy
- Presence of scalp injury or disease
- Prior history of seizures
- Metal implants in head or neck
- Prior intracranial surgery
- Prior brain radiotherapy
- Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Stimulation (noninvasive recording) transcranial direct current stimulation (noninvasive recording) Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and transcranial direct current stimulation. Sham (noninvasive recording) sham transcranial direct current stimulation (noninvasive recording) Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and sham transcranial direct current stimulation. Stimulation (invasive recording) transcranial direct current stimulation (invasive recording) Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation
- Primary Outcome Measures
Name Time Method Change in primary motor cortical (PriMC) beta oscillations during arm flexion in relation to anodal tDCS activation Subjects will undergo baseline ECoG recording 5 min before tDCS starts, during tDCS (5 min after stimulation starts) and 5 min after tDCS stimulation ends. Measurements will be made similarly during sham stimulation. ECoG is used to track beta spectral power during an arm flexion task in conjuction with transcranial direct current stimulation
Change in primary motor cortical (PriMC) beta oscillations during cued arm reaching in relation to anodal tDCS activation Subjects will undergo baseline EEG recording 5 min before tDCS starts, during tDCS (5 min after stimulation starts) and 5 min after tDCS stimulation ends. Measurements will be made similarly during sham stimulation. EEG is used to track beta spectral power during a cued motor task in conjuction with transcranial direct current stimulation or sham
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States