The effect of red grape seed extract on human semen parameters

Early Phase 1

• Conditions: Male Infertility.; Male Infertility

• Registration Number: IRCT201010034861N1
• Lead Sponsor: Royan Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

Oligozoospermia with sperm count 5-20 million/ml and astenozoospermia with progressive motility less than 40%
Exclusion criteria: Explained infertility (e.g. hormonal disorders, epididimis canal obstruction, epididimorchitis,...) smoking, drug or alcohol addiction, diabetes, renal disorders (creatinine more than 2.0 times), chronic liver diseases (transaminase more than twice as much normal), varicocele, infectious diseases indicated with fever and leukocytosis, sexual arousing-drugs consumption

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sperm Motility. Timepoint: before intervention and a week after intervention. Method of measurement: Motility velocity and percentage.;ROS (Reactive Oxygen Species) levels. Timepoint: before intervention and a week after intervention. Method of measurement: Concentration assay by chemiluminesence method.;Sperm Concentration. Timepoint: before intervention and a week after intervention. Method of measurement: Counting the sperms.

Secondary Outcome Measures

Name	Time	Method
FSH level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.;LH level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.;Testosterone level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.