Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination
- Conditions
- Septic Shock
- Interventions
- Device: Cytokine absorption
- Registration Number
- NCT04259567
- Lead Sponsor
- Johannes Gutenberg University Mainz
- Brief Summary
The trial investigates the effect of cytokine elimination in patients with septic schock and acute renal failure with need for renal replacement therapy on the integrity of cerebrovascular autoregulation. Patients with inclusion criteria were randomly assign in either use of CytoSorb filter integrated in renal replacement therapy versus non additional filter an renal replacement therapy alone. Cerebrovascular autoregulation will be measured with transcranial Doppler ultrasound and correlation with arterial blood pressure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
- septic shock
- acute renal failure with need for renal replacement therapy
- pregnancy
- nursing
- impossibility to do transcranial Doppler ultrasound
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Filter Cytokine absorption Patients with CytoSorb absorber
- Primary Outcome Measures
Name Time Method Differences in the index of cerebrovascular autoregulation (Mx) between both groups days 1 to 4 after diagnosis of septic shock Integrity of the cerebrovascular autoregulation will be measured using the index of cerebrovascular autoregulation Mx (moving correlation index). Outcome is the difference of the mean Mx between both groups and, therefore, the difference of integrity of the cerbrovascular autoregulation. A difference of 0.2 in Mx was set as clinically relevant.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Medical Center of the Johannes Gutenberg-Univerity
🇩🇪Mainz, Germany