Breaking up Sedentary Time in Rheumatoid Arthritis
- Conditions
- Endothelial DysfunctionRheumatoid ArthritisSedentary Behavior
- Interventions
- Behavioral: Physical activity
- Registration Number
- NCT05284110
- Lead Sponsor
- Liverpool John Moores University
- Brief Summary
This study will verify the effects of breaking up sitting time with short bouts of light intensity walking on vascular function in women with rheumatoid arthritis.
- Detailed Description
Women diagnosed with rheumatoid arthritis will participate in this randomized crossover trial. In one of the experimental sessions, the participants will remain 4-h on uninterrupted sitting, and in another day they will perform 3-min light intensity walk every 30 min to break up the sitting position. Vascular function will be assessed before and after each intervention using the following devices/techniques: a) transcranial Doppler ultrasound to assess the middle cerebral artery blood flow velocity at baseline and in response to CO2 breathing (5% CO2 mixture for 3 min), and to repeated sit-to-stand transitions; b) a multi-frequency linear transducer (7-12 MHz) attached to a high-resolution ultrasound machine to assess femoral artery dilation after reactive hyperemia (i.e., flow-mediated dilation); c) a laser Doppler probe attached to the skin surface of the right shin in order to quantify the Laser Doppler flux at baseline and during reactive hyperemia. Additionally, healthy age- and body mass-matched women will be recruited and will only perform the pre-intervention tests.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 12
- Adult women diagnosed with RA
- From the Rheumatology Clinic at the Liverpool University Hospitals NHS Foundation Trust
- Aged 18-60 yr
- Non-smoker for at least 6months
- Able to provide written informed consent.
- Cannot readily read and understand English.
- Currently smoking or within last 6 months.
- Alcohol consumption >14units per week.
- Symptoms of or established cardiovascular disease (except hypertension)
- Previous stroke or myocardial infarction.
- History of diabetes or respiratory disease or chronic kidney disease.
- Musculoskeletal impairment/disability precluding physical activity
- Unstable medication (change in medication within the 3 months)
- Aged <18 or > 60 yr
- Currently pregnant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Walking breaks (WALK) Physical activity During this session, participants will be requested to remain seated during 4 hours, but the sitting will be interrupted every 30 min with a 3-min light-intensity walking.
- Primary Outcome Measures
Name Time Method Middle cerebral artery mean velocity (MCAV) Change from baseline (hour 0) to hour 4 (post-intervention/control) MCAV will be assessed using continuous bilateral transcranial Doppler ultrasound.
Middle cerebral artery mean velocity reactivity to carbon dioxide Change from baseline (hour 0) to hour 4 (post-intervention/control) Participants will breathe a 5% carbon dioxide mixture for 3 min during which time MCAV reactivity to CO2 will be assessed using continuous bilateral transcranial Doppler ultrasound.
Cerebral autoregulation Change from baseline (hour 0) to hour 4 (post-intervention/control) Participants will be asked to complete a series of repeated sit to stand moves (coached by a member of the research team) for a 5-minute period, during which time MCAV will be assessed using continuous bilateral transcranial Doppler ultrasound. Beat by beat blood pressure will also be assessed using finger photoplethysmography.
- Secondary Outcome Measures
Name Time Method Brachial artery endothelial function Change from baseline (hour 0) to hour 4 (post-intervention/control) Brachial artery endothelial function will be assessed through flow-mediated dilation using vascular ultrasound.
Brachial artery blood flow Change from baseline to 1-hour/2-hour/3-hour/4-hour Vascular ultrasound will be used to assess brachial artery blood flow every hour during the intervention
Femoral artery blood flow Change from baseline to 1-hour/2-hour/3-hour/4-hour Vascular ultrasound will be used to assess femoral artery blood flow every hour during the intervention
Pain intensity Change from baseline to 1-hour/2-hour/3-hour/4-hour Pain intensity will be assessed using a 10cm visual analogue scale.
Finger blood pressure Change from baseline (hour 0) to hour 4 (post-intervention/control) During all procedures, beat by beat finger blood pressure will be measured on the middle finger of the right hand using photoplethysmography.
Skin blood flow response to hyperemia Change from baseline (hour 0) to hour 4 (post-intervention/control) Skin blood flow response to hyperemia will be assessed using a laser doppler probe attached to the shin and forearm.
Stroop color-word test Change from baseline (hour 0) to hour 4 (post-intervention/control) The Stroop color-word test will be implemented to assess attention and inhibitory control.
Superficial femoral artery endothelial function Change from baseline (hour 0) to hour 4 (post-intervention/control) Superficial femoral artery endothelial function will be assessed through flow-mediated dilation using vascular ultrasound.
California Verbal Learning Test-2 Change from baseline (hour 0) to hour 4 (post-intervention/control) Immediate recall of the California Verbal Learning Test-2 will be used to assess verbal learning and memory.
Trial Locations
- Locations (1)
Research Institute for Sport and Exercise Sciences (RISES)
🇬🇧Liverpool, Merseyside, United Kingdom