Myocardial Ischemia in Non-obstructive Coronary Artery Disease

Completed

• Conditions: Coronary Atherosclerosis; Myocardial Ischemia

• Registration Number: NCT01853527
• Lead Sponsor: University of Bergen

Brief Summary

The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.

Detailed Description

Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-05-07
• Study First Submitted QC: 2013-05-10
• Study First Posted: 2013-05-15
• Primary Completion: 2015-05
• Study Completion: 2017-12
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-05
• Last Update Posted: 2018-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 132

Inclusion Criteria

• Age >30 years
• Chest pain and or functional dyspnoea with a duration > 6 months
• Non-obstructive coronary artery disease detected by CT coronary angiography

Exclusion Criteria

• Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography
• Unstable coronary artery disease
• Significant valvular heart disease
• Mechanical valve prosthesis
• Significant arrhythmia
• Severly reduced pulmonary function (GOLD 3-4)
• Known allergy to ultrasound contrast agents
• Pregnancy
• Inability to sign informed consent to participate
• Other severe disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of myocardial ischemia by contrast stress echocardiography	15 minutes, during contrast stress echocardopgraphy	Presence of delayed myocardial contrast enhancement during stress echocardiography

Secondary Outcome Measures

Name	Time	Method
Extent of myocardial ischemia by contrast stress echocardiography	15 minutes, during contrast stress echocardiography	Numbers of left ventricular segments with delayed contrast enhancement during stress echocardiography

Trial Locations

Locations (1)

Department of Heart Disease, Haukeland University Hospital; 🇳🇴 Bergen, Norway