Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT

• Conditions: Glaucoma; Myopia

• Registration Number: NCT00741130
• Lead Sponsor: Yonsei University

Brief Summary

Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc. In the present study, the corrected RNFL thickness by the optic nerve head configuration using the Cirrus HD OCT will be evaluated. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Detailed Description

Finding the localized retinal nerve fiber layer (RNFL) defect and measuring the RNFL thickness are two main issues for early glaucoma detection. A recently developed imaging device, the Cirrus HD OCT, offers more detailed informations about retina architecture including optic nerve head. To calculate the RNFL thickness, the software of the Cirrus HD OCT supposes an ideal optic nerve head. However, in the cases with not ideal optic disc configuration, the measurement of the RNFL thickness is not correct. Because the measurement of the RNFL thickness is extremely sensitive to the position of measurement, patients with the tilted disc are in danger of misdiagnosis. In the present study, we want to correct the RNFL thickness measurement according to the optic nerve head configuration using the Cirrus HD OCT. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Study Timeline

• Study Start: 2008-07
• Status Verified: 2008-08
• Study First Submitted: 2008-08-25
• Study First Submitted QC: 2008-08-25
• Last Update Submitted: 2008-08-25
• Study First Posted: 2008-08-26
• Last Update Posted: 2008-08-26
• Primary Completion: 2008-10
• Study Completion: 2009-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• normal controls or glaucoma patients
• signal intensity of the OCT image > 8
• cooperative subjects

Exclusion Criteria

• spherical equivalent refractive errors > +4 diopters or < -4 diopters
• significant media opacity
• previous intraocular surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the Cirrus HD OCT	when the OCT images are taking

Secondary Outcome Measures

Name	Time	Method
automated visual field	when the OCT images are taking
red-free fundus photo	when the OCT images are taking
refractive errors	when the OCT images are taking

Trial Locations

Locations (1)

Gong Je Seong; 🇰🇷 Seoul, Korea, Republic of