Timolol Eye Drops in the Treatment of Acute Migraine Headache
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Timolol Eye Drops in the Treatment of Acute Migraine Headache
研究概览
简要总结
The goal of this study is to determine whether timolol eye drops are effective in alleviating acute migraine headaches. Subjects will be randomized to receive either timolol eye drops or placebo (tears) to use as a migraine abortive medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of migraine headache
- •Exclusion Criteria
- •Non-migraine headache
- •Use of systemic beta-blocker
- •Medical history of hypotension, bradycardia, syncope or other significant cardiovascular disease
- •Medical history of difficulty breathing, asthma or chronic obstructive pulmonary disease or other pulmonary disease
- •Medical history of glaucoma, ocular hypertension or hypotony, punctual stenosis, current use of other ophthalmic medications
- •Previous adverse reaction to timolol or other beta-blockers
- •Inability to self-administer eye drop due to physical or cognitive disorders
- •Currently pregnant or breastfeeding
- •Pregnant in the past year
- •Non-english speaker
排除标准
- 未提供
研究组 & 干预措施
Timolol eye drops
All subjects received timolol eye drops or placebo (artificial tears) for two months then crossed over to the opposite medication for the final two months of the study.
干预措施: Timolol eye drops (Drug)
Artificial tears
All subjects received timolol eye drops or placebo (artificial tears) for two months then crossed over to the opposite medication for the final two months of the study.
干预措施: Artificial tears (Drug)
结局指标
主要结局
Timolol Eye Drops in the Treatment of Acute Migraine Headache
时间窗: 4 months
Percent of migraine attacks at 0 or 1 on the 4-point Rating Scale recommended by the International Headache Society: 0: no headache 1. mild headache 2. moderate headaches 3. severe headache
次要结局
未报告次要终点
研究者
Sean Gratton
Assistant Professor and Staff Physician
University of Missouri, Kansas City