Orally Administered ENT-01 for Parkinson's Disease-Related Constipation Follow-on Safety "Roll-over" Study (Rollover)

Phase 2

Terminated

• Conditions: Parkinson Disease; Constipation
• Interventions: Drug: Active Investigational Treatment ENT-01

• Registration Number: NCT04483479
• Lead Sponsor: Enterin Inc.

Brief Summary

This study will be conducted as an open-label safety follow-on to a multi-center, double-blind, randomized study. All subjects who participated in the randomized study will be offered participation in this unblinded, single-arm, safety study. Approximately 50 subjects will be entered into the study and ENT-01 will be administered daily in escalating doses followed by a fixed dose for 12 weeks. Each subject will participate for approximately 20 weeks; dosing duration will be approximately 14 weeks.

Detailed Description

The study will be conducted on an out-patient or in-patient basis with visits performed at the screening visit, at 6 and 12 weeks, and at the end of the 6th week of the wash-out period (end of study).

The dose escalation period will last up to 20 days, the fixed dose period will last 12 weeks, and the wash-out period will last 6 weeks.

Subjects will begin dosing at the same dose level they were stratified to in the ENT-01-030 randomized study (i.e., starting at either 3 tablets or 6 tablets,) and escalate up to a pro-kinetic dose or a maximum dose of 250mg.

Study Timeline

• Study First Submitted: 2020-07-20
• Study First Submitted QC: 2020-07-22
• Study First Posted: 2020-07-23
• Study Start: 2020-07-30
• Primary Completion: 2022-02-17
• Study Completion: 2022-02-17
• Results First Submitted: 2023-10-03
• Status Verified: 2024-02
• Results First Submitted QC: 2024-02-20
• Last Update Submitted: 2024-02-20
• Results First Posted: 2024-03-19
• Last Update Posted: 2024-03-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

1. All subjects who participated in the randomized study ENT-01-030 (KARMET Stage 2 Extension subjects) and who completed the dosing period.
2. Subjects aged 30-90 years at the time of screening for the ENT-01-030 study, both genders
3. Subjects must provide informed consent and be willing and able to comply with study procedures.
4. Subjects must be able to read, understand, and accurately record data into the diary to guarantee full participation in the study.
5. Female subjects must have negative serum or urine pregnancy tests and must not be lactating. For females able to bear children, a hormonal (i.e., oral, implantable, or injectable) and single-barrier method, or a double-barrier method of birth control must be used throughout the study. A vasectomized partner will be allowed as one in conjunction with another single-barrier method.
6. Female subjects unable to bear children must have this documented in the CRF (i.e., tubal ligation, hysterectomy, or postmenopausal [defined as a minimum of one year since the last menstrual period]). Post-menopausal status will be confirmed by follicle stimulating hormone (FSH) in women less than 60 years of age.

Exclusion Criteria

1. Unable or unwilling to provide informed consent or to comply with study procedures.

2. Unable to withdraw proton pump inhibitors.

3. Unable or unwilling to withdraw from laxatives, opiates, clonazepam, or any medications which may cause constipation 2 weeks prior to the dose adjustment period and throughout the rest of the study.

4. Diagnosis of secondary constipation beyond that of Parkinson's disease.

5. A compromised gastrointestinal system which includes:

   • Structural, metabolic, or functional GI diseases or disorders.
   • Acute GI illness within 2 weeks of the screening visit.
   • History of major GI surgery within 30 days of the screening visit (a history of cholecystectomy, polypectomy, hernia repair or appendicectomy are not exclusionary as long as they were performed more than 30 days before the screening visit).

6. Neurological disorder other than Parkinson's disease that in the opinion of the investigator might interfere with the conduct of the study.

7. On treatment with intra-jejunal dopamine or carbidopa/levodopa (i.e. Duopa).

8. Subjects starting a new Parkinson's disease medication or modifying an existing medication within 2 weeks prior to enrollment.

9. Unable to maintain a stable diet regimen.

10. Subjects with a cognitive impairment that preclude them from understanding the informed consent.

11. Subjects placed under legal guardianship.

12. History of excessive alcohol use or substance abuse.

13. Any clinically significant abnormalities on screening laboratories or physical examination requiring further evaluation or treatment.

14. Females who are pregnant or breastfeeding.

15. Subject or caregiver unable to administer daily oral dosing of study drug.

16. Participation in a non-Enterin investigational drug trial within the month prior to dosing in the present study.

17. Any other reason, which in the opinion of the investigator would confound proper interpretation of the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Active Treatment	Active Investigational Treatment ENT-01	Orally Administered ENT-01 25mg Tablet Once Daily (Dose dependent on ENT-01-030 dose level stratification)

Primary Outcome Measures

Name	Time	Method
Number of Participants With Treatment Related Adverse Events	Through study treatment and completion up to 14 weeks	Number of participants with Treatment Related Adverse Events
Number of Participants With Treatment Related Recurrent Vomiting	Through study treatment and completion up to 14 weeks	The number of participants with treatment related episodes of recurrent vomiting defined as 3-5 episodes of vomiting within 24 hours
Number of Participants With Treatment Related Recurrent Diarrhea	Through study treatment and completion up to 14 weeks	The number of participants with treatment related episodes of recurrent diarrhea defined as 7 episodes of diarrhea within 24 hours for 2 consecutive days
Number of Participants With Treatment Related Dizziness	Through study treatment and completion up to 14 weeks	The number of participants with treatment related episodes of dizziness defined as lightheadedness or fainting on rising from lying to sitting or standing and severe enough to require non-urgent medical intervention within 24 hours

Trial Locations

Locations (18)

Intercoastal Medical Group; 🇺🇸 Sarasota, Florida, United States

Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States

University of Toledo Medical Center; 🇺🇸 Toledo, Ohio, United States

Evergreen Health - Booth Gardner Parkinson's Care Center; 🇺🇸 Kirkland, Washington, United States

Parkinson's Disease and Movement Disorders Center of Boca Raton; 🇺🇸 Boca Raton, Florida, United States

Premiere Research Institute at Palm Beach Neurology; 🇺🇸 West Palm Beach, Florida, United States

Rocky Mountain Movement Disorders Center; 🇺🇸 Englewood, Colorado, United States

Penn State University; 🇺🇸 Hershey, Pennsylvania, United States

Parkinson's Disease Treatment Center of SWFL; 🇺🇸 Port Charlotte, Florida, United States

The Parkinson's and Movement Disorder Institute; 🇺🇸 Fountain Valley, California, United States

SC3 Research - Pasadena; 🇺🇸 Pasadena, California, United States

Albany Medical College; 🇺🇸 Albany, New York, United States

Icahn School of Medicine at Mount Sinai; 🇺🇸 New York, New York, United States

USF Health Byrd Parkinson's Disease Movement Disorders Center of Excellence; 🇺🇸 Tampa, Florida, United States

Georgetown Universtiy, Department of Neurology; 🇺🇸 Washington, District of Columbia, United States

JEM Research Institute; 🇺🇸 Atlantis, Florida, United States

Dartmouth Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States

University Physicians & Surgeons, Inc. dba Marshall Health; 🇺🇸 Huntington, West Virginia, United States