Plasma Levels of Human Leucocyte Antigen G in Patients With Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To measure the polymorphisms of Human Leucocyte Antigen G (HLA-G) gene
研究概览
简要总结
The Human leukocyte antigen G (HLA-G) is a non-classical, major histocompatibility complex class I (MHC-I) protein that modulates the immune response, inhibiting it in most cases. Physiologically expressed in the cells of some tissues, it increases in inflammatory reactions. Inflammation appears to play an important role in the development of chronic heart failure. This study aims to evaluate the levels of soluble HLA-G in patients with heart failure and to investigate the relationships between HLA-G and other clinical-functional parameters of the disease. Investigators hypothesize that the plasma levels of HLA-G could correlate with the clinical status of heart failure and could provide indications on patient's prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with recent diagnosis of chronic heart failure as defined by the guidelines of the European Society of Cardiology (ESC) and with cardiac ejection fraction <
- •Clinical stability in the previous month prior to recruitment.
- •Absence of coexisting autoimmune diseases.
排除标准
- •Subjects with over one year chronic heart failure diagnosis and in clinical stability for less than 1 month.
- •Presence of autoimmune diseases.
结局指标
主要结局
To measure the polymorphisms of Human Leucocyte Antigen G (HLA-G) gene
时间窗: Collection of whole blood at baseline
To analyze the polymorphisms (Insertion/Deletion 14 pb and 3142 C\>G) of the HLA-G gene in patients with chronic heart failure (CHF) at baseline
To measure plasma levels of soluble Human Leucocyte Antigen G (HLA-G) in patients with chronic heart failure (CHF)
时间窗: Collection of whole blood at baseline, at 6 and 12 months from baseline
To measure the plasmatic levels of HLA-G in patients with stable chronic heart failure at baseline. To assess possible changes in HLA-G levels, due to CHF exacerbations, at 6 and 12 months from baseline
次要结局
- To correlate the plasma levels of HLA-G with clinical-functional parameters of the chronic heart failure (CHF) in patients with CHF(At baseline and after 12 months)
研究者
Piera Boschetto
Professor
University Hospital of Ferrara