Effect of intravenous lidocaine on propofol narcosis
- Conditions
- the effects of intravenous application of lidocaine on the Cp50 during propofol narcosis should be investigatedTherapeutic area: Body processes [G] - Chemical Phenomena [G02]
- Registration Number
- EUCTR2011-000022-29-AT
- Lead Sponsor
- Medizinische Universität Wien
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
operation under general anaesthesia
insertion of LMA possible
age 20-60 years
ASA 1-2
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 36
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
premedication
tracheal intubation
allergy to lidocaine
body mass index > 30
history of esophageal reflux, hiatal hernia, peptic ulcer disease
significant cardiovascular, respiratory, renal or hepatic disease
history of alcohol or drug abuse
pregnancy
arrhythmias
epilepsy
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: to evaluate the effect of intravenous lidocaine on the Cp50 of propofol;Secondary Objective: to evaluate the effect of intravenous lidocaine on BIS and hemodynamics;Primary end point(s): movement or no movement at skin incision;Timepoint(s) of evaluation of this end point: skin incision
- Secondary Outcome Measures
Name Time Method Secondary end point(s): BIS and hemodynamic changes at skin incision;Timepoint(s) of evaluation of this end point: skin incision