Maternal and neonatal effects of remifentanil in women undergoing ceasarean section in relation to multidrug resistance protein 1 (MDR1) and mu-opioid receptor (OPRM) polymorphisms
Recruiting
- Conditions
- pregnant women with hypertension, chronic or gestational, including preeclampsia indicated to caesarean sectionAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12612001165875
- Lead Sponsor
- Interni grantove agentury Ministerstva zdravotnictvi (IGA)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 160
Inclusion Criteria
cesarean section, hypertension, preeclampsia
Exclusion Criteria
multiparity, gestational age < 35 weeks, estimated fetal weight < 2500g, hypoxia or signs of fetal stress and mother´s hypotension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sufficiency of anesthesia - suppression of autonomic reactions by blood pressure measurement (systolic arterial pressure, mean arterial pressure, heart rate)[Values will be noted at 2.5 min intervals during 15 minutes from the beginning till the end of the caesarean section. Also time note of the following events: transfer to operation hall, administration of remifentanil, laryngoscopy and endotracheal intubation, skin incision, uterine incision, delivery, the end of the operation and extubation will be noted.];depth of anesthesia - the bispectral index (BIS)[Values will be noted at 2.5 min intervals during 15 minutes from the beginning till the end of the caesarean section.];course of anesthesia - pulse oximetry (SpO2), capnography, inspired oxygen fraction, inspired and expired gas fraction.[Values will be noted at 2.5 min intervals during 15 minutes from the beginning till the end of the caesarean section.]
- Secondary Outcome Measures
Name Time Method neonatal characteristics - Apgar score[Neonates will be evaluated by standart Apgar score at 1st, 5th and 10th minute.];Resuscitative measures of newborn - bag-mask ventilation, tactile stimulation, oxygen tubing[Neonates will be monitored 10min after birth for possible respiratory depression.]