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Exelixis

Exelixis logo
🇺🇸United States
Ownership
Public
Established
1994-01-01
Employees
1.3K
Market Cap
$7.3B
Website
http://www.exelixis.com
Introduction

Exelixis, Inc. operates as an oncology company, which focuses on discovering, developing, and commercialization of new medicines for difficult-to-treat cancers. Its products include cabometyx, cometriq, and cotellic. The company was founded by Stelios Papadopoulos on November 15, 1994, and is headquartered in Alameda, CA.

Clinical Trials

155

Active:107
Completed:23

Trial Phases

5 Phases

Phase 1:111
Phase 2:7
Phase 3:16
+2 more phases

Drug Approvals

2

FDA:2

Drug Approvals

CABOMETYX

Approval Date
Sep 29, 2023
FDA

COMETRIQ

Approval Date
Aug 23, 2023
FDA

Clinical Trials

Distribution across different clinical trial phases (137 trials with phase data)• Click on a phase to view related trials

Phase 1
111 (81.0%)
Phase 3
16 (11.7%)
Phase 2
7 (5.1%)
Phase 4
2 (1.5%)
Not Applicable
1 (0.7%)

A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Not Applicable
Recruiting
Conditions
Solid Tumors
Interventions
First Posted Date
2025-08-14
Last Posted Date
2025-08-28
Lead Sponsor
Exelixis
Target Recruit Count
150
Registration Number
NCT07123103
Locations
🇺🇸

Exelixis Clinical Site #2, Huntersville, North Carolina, United States

🇺🇸

Exelixis Clinical Site #1, San Antonio, Texas, United States

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

Phase 1
Recruiting
Conditions
Hepatic Impairment
Moderate Hepatic Impairment
Interventions
First Posted Date
2025-05-08
Last Posted Date
2025-06-22
Lead Sponsor
Exelixis
Target Recruit Count
20
Registration Number
NCT06962332
Locations
🇺🇸

Exelixis Clinical Site #1, Orlando, Florida, United States

🇺🇸

Exelixis Clinical Site #2, San Antonio, Texas, United States

A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

Phase 1
Recruiting
Conditions
Solid Tumor
Metastatic Solid Tumor
Advanced Solid Tumor
Immune Sensitive Tumor
Interventions
First Posted Date
2025-04-30
Last Posted Date
2025-09-08
Lead Sponsor
Exelixis
Target Recruit Count
75
Registration Number
NCT06952010
Locations
🇺🇸

Exelixis Site #4, New Haven, Connecticut, United States

🇺🇸

Exelixis Clinical Site #1, Hickory, North Carolina, United States

🇺🇸

Exelixis Clinical Site #3, Nashville, Tennessee, United States

and more 1 locations

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

Phase 2
Recruiting
Conditions
Pancreatic Neuroendocrine Tumor (pNET)
Extra-Pancreatic Neuroendocrine Tumor (epNET)
Interventions
First Posted Date
2025-04-24
Last Posted Date
2025-09-26
Lead Sponsor
Exelixis
Target Recruit Count
440
Registration Number
NCT06943755
Locations
🇺🇸

Exelixis Clinical Site #9, Lexington, Kentucky, United States

🇺🇸

Exelixis Clinical Site #8, Boston, Massachusetts, United States

🇺🇸

Exelixis Clinical Site #1, Grand Rapids, Michigan, United States

and more 6 locations

A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors

Phase 1
Terminated
Conditions
Solid Cancers
Solid Tumor Cancer
Solid Tumor Malignancy
Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
Metastatic Solid Tumor
Locally Advanced Solid Tumor
Urothelial Cancer of Renal Pelvis
Interventions
Drug: ADC cytotoxic agents
First Posted Date
2024-10-08
Last Posted Date
2025-06-25
Lead Sponsor
Exelixis
Target Recruit Count
9
Registration Number
NCT06630247
Locations
🇺🇸

Exelixis Clinical Site #4, Denver, Colorado, United States

🇺🇸

Exelixis Clinical Site #9, New Haven, Connecticut, United States

🇺🇸

Exelixis Clinical Site #8, Washington, District of Columbia, United States

and more 7 locations
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News

Ryvu Therapeutics Partners with BioNTech to Accelerate Cancer Immunotherapy Trials in Poland

Ryvu Therapeutics has entered a strategic agreement with BioNTech to support clinical trial site activation and patient recruitment for multiple investigational cancer immunotherapies in Poland.

Exelixis Promotes Dana Aftab to Lead Consolidated R&D Operations Amid Strategic Restructuring

Exelixis has promoted Dana T. Aftab, Ph.D., to Executive Vice President of Research and Development, consolidating discovery, translational research, and late-stage development under unified leadership.

Exelixis Closes Pennsylvania Facility, Cuts 130 Jobs in Strategic Consolidation

Exelixis will close its King of Prussia, Pennsylvania facility and lay off 130 employees, representing an 11% workforce reduction as the company consolidates operations in California.

Zentalis Pharmaceuticals Appoints James B. Bucher as Chief Legal Officer to Support Azenosertib's Advancement

Zentalis Pharmaceuticals has appointed James B. Bucher as Chief Legal Officer and Corporate Secretary, effective September 18, 2025, bringing over 30 years of life sciences legal experience.

BioNTech's BNT113 mRNA Cancer Vaccine Advances in Phase 2 Trial for HPV+ Head and Neck Cancer

BioNTech's BNT113, an mRNA cancer vaccine targeting HPV16+ oncoproteins E6 and E7, is being evaluated in the Phase 2 AHEAD-MERIT trial combined with pembrolizumab versus pembrolizumab alone for unresectable recurrent or metastatic HPV+ head and neck squamous cell carcinoma.

Major Pharmaceutical Companies Face Surge in Generic Drug Patent Challenges in Early 2025

Major pharmaceutical companies including AstraZeneca, Novartis, and Astellas are defending patents for blockbuster drugs like Lynparza, Entresto, and Xtandi against generic manufacturers in early 2025.

Bristol-Myers Squibb, Exelixis, and Novartis Advance Pan-Tumor Rollover Study for Long-Term Nivolumab Safety Assessment

Bristol-Myers Squibb, Exelixis, and Novartis are collaborating on the Pan-Tumor Rollover Study to evaluate the long-term safety of nivolumab monotherapy and its combinations across various tumor types.

Comprehensive Pipeline Analysis Reveals 200+ Investigational Drugs for Metastatic Hormone Refractory Prostate Cancer

A new comprehensive report analyzes over 200 pipeline drugs from 180+ companies targeting metastatic hormone refractory prostate cancer, highlighting the extensive research efforts in this challenging therapeutic area.

Dual-Payload ADCs Enter Clinical Testing as Innovent and Chengdu Kanghong Pioneer Next-Generation Cancer Therapeutics

Innovent's IBI3020, a dual-payload ADC targeting CEACAM5, has begun first-in-human trials for solid tumors, marking a significant milestone in next-generation cancer therapeutics.

Exelixis Reports Promising Results for Zanzalintinib Combination in Advanced Kidney Cancer

Zanzalintinib combined with nivolumab demonstrated a 63% objective response rate and 90% disease control rate in previously untreated advanced clear cell renal cell carcinoma patients.

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