Resistance Exercise Reduces the Expression of Inflammation and Fibrosis Associated Genes in Autoimmune Myositis Patients

Not Applicable

Completed

• Conditions: Myositis; Exercise
• Interventions: Other: exercise

• Registration Number: NCT00519103
• Lead Sponsor: Karolinska Institutet

Brief Summary

The aim of this study was to investigate the effects of physical exercise on gene expression in muscle biopsies from patients with chronic polymyositis or dermatomyositis

Detailed Description

Eight patients with polymyositis or dermatomyositis according to the Bohan and Peter criteria and who had all participated in a resistive exercise trial at Karolinska University Hospital, Stockholm, Sweden, were included in this study. Patients were included if they had a disease duration more than 12 months and they had to have a stable, low disease activity and medication for three months before enrollment in the study. Patients with inclusion body myositis were excluded as well as patients with co morbidities that contradicted vigorous exercise (severe osteoporosis with multiple fractures, malignant disease severe lung disease) or if they were physically active more than once a week. The median disease duration at time of study start was 4.5 years (range 2,7-29 year). All patients had been treated with glucocorticoids and other immunosuppressive therapies with some improvement of muscle function but with persisting muscle impairment. At time of study seven patients were still on immunosuppressive treatment, five were taking prednisone with a median dosage of 2.5 mg/day (range 0-6.25 mg/d). Six patients were treated with azathioprine, one in combination with cyclosporine A, one patient was treated with methotrexate and one with IVIG 2g/kg body weight every three months

Study Timeline

• Study Start: 2002-12
• Study Completion: 2003-03
• Status Verified: 2007-08
• Study First Submitted: 2007-08-20
• Study First Submitted QC: 2007-08-20
• Study First Posted: 2007-08-21
• Last Update Submitted: 2007-08-29
• Last Update Posted: 2007-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Patients were included if they had a disease duration more than 12 months and they had to have a stable, low disease activity and medication for three months before enrollment in the study

Exclusion Criteria

• Patients with inclusion body myositis were excluded as well as patients with co morbidities that contradicted vigorous exercise (severe osteoporosis with multiple fractures, malignant disease severe lung disease) or if they were physically active more than once a week.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	exercise	Active resistive excercise for 7 weeks

Primary Outcome Measures

Name	Time	Method
effects of physical exercise muscle strength and function in patients with chronic polymyositis or dermatomyositis	7weeks

Secondary Outcome Measures

Name	Time	Method
effects of exercise on gene expression and corresponding protein expression in muscle tissue and on signs of inflammation in peripheral blood	7 weeks

Trial Locations

Locations (1)

Rheumatology unit, Karolinska Unirversity hospital; 🇸🇪 Stockholm, Sweden