Investigation of the Effects of Exercise on Gene Expression
- Conditions
- Healthy
- Interventions
- Other: exercise training
- Registration Number
- NCT00916019
- Lead Sponsor
- Fukuoka University
- Brief Summary
The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 6
- Men who were all in good health
- All individuals were free from diabetes and none were taking any medications
- All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity
- People who undergone regular exercise for at least 2 years
- Smokers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description exercise exercise training mild exercise training
- Primary Outcome Measures
Name Time Method Skeletal muscle PGC-1alpha gene expression and mitochondrial gene expression 3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fukuoka University
🇯🇵Fukuoka, Japan