Monitoring of training effects with gene expression patterns of athletes

Completed

Conditions: vermogen tot herstel van lichte spierschade en adaptatie aan inspanning en training bij gezonde personen
mild muscle damage due to normal exercise and training

Registration Number: NL-OMON46884

Lead Sponsor: Stichting Hogeschool Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Healthy males
-18-50 years old
- Recreationally trained track or road cyclists (VO2-max >= 45ml/kg/min), with at least two years of cycling experience of at least twice a week
- Meeting criteria of a valid maximal incremental exercise test
- Body mass index (BMI) 20-25 kg/m2
- Veins suitable for blood sampling at inspection
- Based on the outcome of the anamnesis form, participants should be rated as low risk participants

Exclusion Criteria

Men with health problems and/or without sporting activity or above 50 years old
- Known diagnosis of immune disease such as diabetes, coeliac disease, rheumatoid arthritis
- Known diagnosis of gastro-intestinal disease such as Crohn*s disease, colitis ulcerosa, irritable bowel syndrome
-Smoking
-Use of hard drugs
-Use of specific medicines:
*chronic use of NSAIDs: aspirin, ibuprofen, corticosteroids
*chronic use of antidepressiva, antacids (Rennie), benzodiazepines (Valium
* drugs against abdominal pain and cramping (e.g.buscopan, imodium),
-Participation in other scientific studies within 1 month before the preliminary testing

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>RNA-profiles of blood cells, as indication of functional alterations in gene<br /><br>expression in leukocytes.<br /><br>Exercise performance parameters as described in the model by Joyner and Coyle<br /><br>(2008) as determined measured during the maximal incremental exercise tests at<br /><br>the start and end of the project: Performance VO2 - VO2max, VO2 at the<br /><br>ventilatory threshold, performance O2 deficit, gross efficiency, peak power<br /><br>output and average power output attained during a Wingate test.</p><br>

Secondary Outcome Measures