The complete placental transcriptome in health and disease in pregnant Caucasian wome
Not Applicable
- Conditions
- Gene expression in placentas collected from fetuses from pregnancies complicated by preeclampsia or intrauterine growth restriction compared to those from healthy pregnancies.Reproductive Health and Childbirth - Fetal medicine and complications of pregnancy
- Registration Number
- ACTRN12612001179820
- Lead Sponsor
- The University of Adelaide
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 600
Inclusion Criteria
Caucasian women pregnant with singleton, non-smokers, BMI 20-35. Both pregnant mothers and fathers of the pregnancy (where possible) will be asked to supply a saliva sample for genome-wide SNP genotyping.
Exclusion Criteria
non caucasian ethnicity, smokers, BMI over 35 or under 20, non english speaking
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification and expression level of all coding and non-coding RNA in placentas from normal pregnancies and those complicated by preeclampsia (PE) and intrauterine growth restriction (IUGR). We will sequence RNA using the Illumina Hi-Seq platform to generate the data and test the differences between normal and complicated pregnancies using established and custom designed bioinformatics pipelines.[At the time of delivery.]
- Secondary Outcome Measures
Name Time Method o secondary outcome.[NA]