Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

Not Applicable

Completed

• Conditions: Vitamin D Deficiency
• Interventions: Other: 7 continuous days of aerobic training

• Registration Number: NCT02485197
• Lead Sponsor: David Travis Thomas

Brief Summary

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-04-25
• Primary Completion: 2013-10
• Study Completion: 2015-06
• Study First Submitted QC: 2015-06-25
• Study First Posted: 2015-06-30
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-15
• Last Update Posted: 2017-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• 65-75 years of age

Exclusion Criteria

• Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
• Uncontrolled diabetes or hypertension.
• History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
• History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
• Have a diagnosis of osteoporosis (as determined by DXA)
• Participated in a resistance or aerobic training program in the last 3 months
• Engage in more than 1 hr/week of vigorous activity
• Body mass index >29
• On hormone replacement therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low 25(OH)D	7 continuous days of aerobic training	We will recruit individuals with low 25(OH)D (\<30ng/mL).
High 25(OH)D	7 continuous days of aerobic training	We will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the "low 25(OH)D group).

Primary Outcome Measures

Name	Time	Method
Muscle VO2 consumption	Up to 3 months	The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.

Trial Locations

Locations (1)

University of Kentucky; 🇺🇸 Lexington, Kentucky, United States