Prospective analysis of relative morphokinetics as predictors of embryonic developmental potential

• Conditions: N97.0; N97.1; N97.2; N97.3; N97.4; N97.8; N97.9; Z31.2; Female infertility associated with anovulation; Female infertility of tubal origin

• Registration Number: DRKS00022983
• Lead Sponsor: niversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-01
• Study Completion: 2021-11-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

IVF-/ICSI-treatment at Heidelberg University Women's Hospital, fresh cycles, use of time-lapse incubator (EmbryoScope), every patient is only included once

Exclusion Criteria

Endometriosis, PCOS, status post chemotherapy, PGT cycles, IVM cycles, embryo transfer before day 5, no transfer due to OHSS (only for secondary outcome implantation rate), developmental arrest before the 8 cell-stage

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Embryo quality according to Gardner and Schoolcraft (1999) at 114-118 hours post-insemination (IVF/ICSI).<br><br>Categorization according to Cetinkaya et al. (2015):<br>Top Quality (TQ): 3-6AA<br>Good Quality (GQ): 3-6BB, AB oder BA<br>Poor Quality (PQ): Blastocysts of inferior quality.<br>Developmental arrest (AE): Embryos in developmental arrest after the 8-cell stage.<br><br>Gardner and Schoolcraft, 1999, In vitro culture of human blastocysts, in: Towards reproductive certainty, S. 378-388.<br>Cetinkaya et al., Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points. J Assist Reprod Genet. 2015;32(1):27-35. doi: 10.1007/s10815-014-0341-x.

Secondary Outcome Measures

Name	Time	Method
Implantation rate: The number of gestational sacs observed divided by the number of embryos transferred (expressed as a percentage, %).<br><br>Zegers-Hochschild et al., 2017, Human Reproduction, 32(9):1786-1801.