The effects of midazolam and flumazenil on cerebral circulatio
Not Applicable
- Conditions
- healthy subjects
- Registration Number
- JPRN-UMIN000012777
- Lead Sponsor
- Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine
- Brief Summary
During midazolam sedation, BIS index, MAP, CBF velocity, and transfer function gain decreased significantly compared with baseline. After administration of flumazenil, BIS index and MAP returned to the same level as baseline. However, CBF velocity showed a further significant decrease compared with midazolam sedation, and the decreased transfer function gain persisted. The present study suggest that despite complete antagonism of the sedative effects of midazolam, flumazenil dose not reverse the alterations in cerebral circulation induced by midazolam.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1) Not satisfy selection criteria noted above. 2) Volunteers having allergic factors to foods and/or drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral blood flow velocity, arterial blood pressure, sedation depth, and cerebral circulation.
- Secondary Outcome Measures
Name Time Method Heart rate, respiratory condition, and autonomic circulatory regulation.