Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia
- Conditions
- Patients undergoing operations under general anesthesia, not limited to specific diseases
- Registration Number
- JPRN-UMIN000001293
- Lead Sponsor
- Department of Anesthesiology, Osaka City University Graduate School of Medicine
- Brief Summary
Plasma and simulated effect site concentrations of midazolam decreased rapidly and were significantly higher in the large-dose group than in the small-dose group (P = 0.005 and < 0.001, respectively). Both BIS and relative beta ratio decreased after induction and remained between 60 and 70, between -1.8 and -1.2, respectively. No differences were observed in BIS, relative beta ratio or 95% spectral edge frequency between the two groups, either. Relative beta ratio significantly correlated with BIS in both groups (r2 = 0.66 and 0.78, respectively, P < 0.001 for both). The electroencephalographic spectral power density in the beta- (&#8805;13 and <30 Hz) band was significantly increased after induction, besides being significantly larger in the large-dose group than in the small-dose group (P = 0.009).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Not provided
1) patients undergoing thoracotomy or lapalotomy, 2) patients with advanced hepatic or renal dysfunction, 3) taking cytochrome P4503A inducers or inhibitors preoperatively, 4) predicted difficulty in tracheal intubation, 5) receiving CYP3A inhibitors during anesthesia, 6) receiving medications affecting electroencephalogram
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method plasma concentration of midazolam, bispectral index, 95% spectral edge frequency
- Secondary Outcome Measures
Name Time Method