Oral Health and Endometriosis: A Cohort Study

Completed

• Conditions: Endometriosis

• Registration Number: NCT06753162
• Lead Sponsor: University of Bari Aldo Moro

Brief Summary

A survey has been conducted thanks to a questionnaire composed of 45 questions. The study group was composed of 4079 women affected by endometriosis, recruited from dedicated communities present on the social network Facebook. The questionnaire investigated about: the endometriosis status, the kind of therapy, the presence of any sign and symptoms in the oral cavity, the presence of periodontal problems, the self-perception of the oral health status, the presence of other autoimmune diseases and oral hygiene and the eating habits, physical activity practiced, the life quality.

Detailed Description

The questions were structured thanks to the collaboration of expert health professionals: gynecologist, dentist, dental hygienist, physiotherapist, dietician, psychologist to obtain targeted information on endometriosis, on the type of therapy, on any signs and symptoms in the oral cavity (perception health status, presence of periodontal problems), to investigate oral hygiene and dietary habits, physical activity, quality of life, the presence of other immune-based diseases. In the final part of the questionnaire there was a section in which women were free to tell their stories.

Study Timeline

• Study Start: 2023-01-01
• Primary Completion: 2023-06-01
• Status Verified: 2024-12
• Study Completion: 2024-12-01
• Study First Submitted: 2024-12-18
• Study First Submitted QC: 2024-12-21
• Last Update Submitted: 2024-12-30
• Study First Posted: 2024-12-31
• Last Update Posted: 2025-01-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 4079

Inclusion Criteria

• The only inclusion criterion was being at least 18 years old

Exclusion Criteria

• • Pregnancy.

  • Administration of antibiotics in the last 15 days prior to entry into the study or indications for antibiotic prophylaxis.
  • Orthodontic Appliances.
  • Immunological diseases or use of drugs that can affect oral tissues (phenytoin, cyclosporine), nifedipine, chronic use of nonsteroidal anti-inflammatory drugs.
  • Refusal to participate in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response Patterns Based on Multiple Correspondence Analysis Dimensions	1 year	To evaluate the possible correlations between endometriosis and the perception of periodontal disease, a score was created to summarize on a numerical scale the responses to survey questions describing the perception of oral cavity disorders. Multiple Correspondence Analysis (MCA) was used to explore relationships between responses. For the MCA, only questions with a p-value \< 0.25 in the univariate analysis were included. The responses to the questions were labeled as "yes," "no," and "I don't know". In the case of question Q11, a grade was assigned to the responses as follows: "Idk" (I don't know), "Grd0" (Insufficient), "Grd1" (Average), "Grd2" (Good), "Grd3" (Very Good), and "Grd4" (Perfect).
Epidemiological Analysis	1 year	It was statistically evaluated whether the severity of endometriosis increased significantly with age.
Comparative Analysis of Oral Cavity Disorders Across Different Stages of Endometriosis	1 year	The correlation between general gum bleeding and the stage of the disease was statistically evaluated.

Trial Locations

Locations (1)

University of Bari Aldo Moro; 🇮🇹 Bari, Italy