TeleRehabilitation in Hypertension

Not Applicable

Completed

• Conditions: Pre-hypertension; Hypertension; Healthy
• Interventions: Other: Isometric handgrip exercise; Other: Aerobic endurance training

• Registration Number: NCT02705911
• Lead Sponsor: KU Leuven

Brief Summary

The purpose of this RCT which will be performed in 60 healthy adults is I. To assess the training effects of 8 weeks of isometric handgrip exercise on BP; and to test whether it yields at least similar effects on BP compared to current exercise recommendations.

II. To assess whether isometric handgrip training yields larger BP reductions beyond the supervised training period at 6 months of follow-up.

III. To determine whether changes in BP following acute exercise and chronic training can be explained by changes in important physiological mechanisms known to mediate or to be associated with BP?

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2016-03-03
• Study First Submitted QC: 2016-03-07
• Study First Posted: 2016-03-11
• Primary Completion: 2016-07
• Study Completion: 2016-07
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-07
• Last Update Posted: 2022-03-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• not physically active (< 3 hours of moderate to high levels of PA/week) low cardiovascular risk according to current guidelines (Mancia et al J Hypertens 2013) will be recruited through advertisements. The latter is defined as:
• >115 mmHg < systolic BP < 139 mmHg and/or 75 mmHg< diastolic BP<90mmHg in the presence of 0 to a maximum of three other cardiovascular risk factors, excluding diabetes Or
• 139 mmHg < systolic BP < 160 mmHg and/or 90 mmHg<DBP< 100 mmHg in the absence of other cardiovascular risk factors

Exclusion Criteria

• current smoker
• pregnancy
• presence of other cardiovascular disease, pulmonary disease or metabolic disease
• inability to perform a standard exercise program due to mental/physical disability.
• use of antihypertensive drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Isometric Handgrip training	Isometric handgrip exercise	Participants are asked to perform daily 4 x 2 minute contractions with alternating hands , separated with 1 minute rest period using a ZonaHealth device;
Aerobic endurance training	Aerobic endurance training	Participants are asked to perform at least 150 minutes extra of moderate aerobic exercise per week

Primary Outcome Measures

Name	Time	Method
change in office blood pressure at 8 weeks of follow-up	8 weeks - 6 months

Secondary Outcome Measures

Name	Time	Method
change in exercise tolerance (peakVO2 in ml/min/kg) at 8 weeks of follow-up	8 weeks - 6 months

Trial Locations

Locations (1)

KU Leuven; 🇧🇪 Leuven, Belgium