nder general anesthesia, three loading doses of dexmedetomidine will be compared for controlled hypotension during functional endoscopic sinus surgery.
Not Applicable
Completed
- Conditions
- Health Condition 1: J329- Chronic sinusitis, unspecifiedHealth Condition 2: J00-J99- Diseases of the respiratory systemHealth Condition 3: O- Medical and Surgical
- Registration Number
- CTRI/2023/04/051531
- Lead Sponsor
- Pt B D Sharma Pgims Rohtak
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Sixty patients aged between 18-60 years of either sex belonging to American Society of Anesthesiology (ASA) I and II scheduled for FESS under general anaesthesia will be included in the study.
Exclusion Criteria
1. Refusal to consent
2. Uncontrolled hypertension
3. Preexisting hypotension (MAP < 70)
4. Heart rate < 60/min
5. Diabetes
6. Coagulation disorders
7. BMI > 35 kg m-2
8. Treatment with beta-blockers
9. Patients scheduled for revision of functional endoscopic sinus surgery
10. Allergy to an alpha 2 adrenergic agonist
11. Pregnancy
12. Anaemia (Hb <10g dl-1)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To achieve and maintain target MAP 60 – 70 mmHg.Timepoint: Before start of surgery 10 minutes after induction of anaesthesia.
- Secondary Outcome Measures
Name Time Method 1. Changes in hemodynamic parameters like heart rate, mean arterial pressure, <br/ ><br>2. Surgical field assessment (Fromme et al. bleeding score) <br/ ><br>3. Surgeon’s satisfaction, (Likert scale) <br/ ><br>4. Minimum alveolar concentration of inhaled anaesthetics (MAC) <br/ ><br>5. Adverse effects, if any <br/ ><br> <br/ ><br>Timepoint: observations will be recorded as baseline, 10 minutes after start of dexmedetomidine loading dose infusion, before induction of anaesthesia, 1, 5 & 10 minutes after tracheal intubation, then every 15 minutes till end of surgery and after tracheal extubation, and also in postoperative period.