The therapeutic effect of inhaled budesonide in patients with unexplained chronic cough.
- Conditions
- unexplained chronic cough.Cough
- Registration Number
- IRCT2013031212419N2
- Lead Sponsor
- The budget will be funded by researchers.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 68
age over 18 years; unexplained chronic cough for more than 8 weeks; absence of underling cardiac diseases; do not using smoking and drugs; absence of clinical and para-clinical asthma evidence; normal chest x-ray; normal spirometry; absence of eosinophilic bronchitis (sputum eosinophil percentage less than 3%); negative (normal) inhaled methacholine provocation test; signed written consent; absence of pregnancy and breast feeding; did not taking steroids during the last 3 months; do not receive any treatment for chronic cough before and during study; do not taking Angiotensin converting enzyme inhibitors (ACEI).
Exclusion criteria: dissatisfaction to continuing cooperation in each stage of the study; exacerbation or other accidents which requiring treatment; lack of returning within 48 hours of the deadline for second visit.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Budesonide inhalation treatment response in Numeric Cough Score questionnaire. Timepoint: Before intervention and a day after it. Method of measurement: Questionnaire.;Budesonide inhalation treatment response in visual analogue scale score. Timepoint: Before intervention and a day after it. Method of measurement: Questionnaire.
- Secondary Outcome Measures
Name Time Method Budesonide inhalation treatment response with Forced Oscillation Technique spirometry parameters. Timepoint: Before intervention in two periods; before and after methacholine challenge test and a day after intervention. Method of measurement: Forced Oscillation Technique spirometry.;Budesonide inhalation treatment response with Fractional Exhaled Nitric Oxide. Timepoint: Before intervention and the day after it. Method of measurement: Fractional Exhaled Nitric Oxide test.