TCTR20240525001尚未招募1 期
The lung Mechanics and PEEP Absorption in patients with Flow limitation during mechanical ventilation: an Analysis by electrical Impedance tomography and Real-time EXpiratory resistance (MAFAI REX)
Faculty of Medicine Ramathibodi Hospital0 个研究点目标入组 125 人开始时间: 2024年5月25日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 125
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •A patient receiving invasive mechanical ventilation via the endotracheal or tracheostomy tube with:
- •1. Age 18 years or more
- •2. Admitted to the intensive and intermediate critical care wards, Ramathibodi hospital
- •3. Have one or more of the following conditions:
- •- Exacerbation of obstructive airway disease (e.g. Asthma, Bronchiectasis, COPD)
- •- Presence of the risk-factor for EFL (e.g. ARDS, Obese patients with respiratory failure, pulmonary edema) with simple PEEP reduction test positive for EFL screening
- •4. Approval by the attending physician to receive sedative and muscle-relaxant agents
- •5. Consented to participate by the next-of-kin
- •6. Permission to perform the study is granted by the attending physician
- •7. Able to perform the study within 48 hours after initiation of invasive mechanical ventilation
排除标准
- •1. Uncorrectable severe hypoxemia defined by PF ratio < 100
- •2. Unstable hemodynamic conditions:
- •- Mean arterial blood pressure < 60 mmHg
- •- Systolic blood pressure > 180 mmHg
- •- Heart rate < 40or > 160 beat per minute
- •3. A patient already enrolled in this study
- •4. The patient or the relatives deny to participate in the study
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