Determination of Citrate Clearance Used in Regional Anticoagulation of Continuous Venous Hemofiltration Circuits
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Citrate concentration - pre-filter
研究概览
简要总结
Citrate anticoagulation is becoming the gold standard in dialysis in intensive care units. It is now accepted that citrate prolongs the life of filters with a lower risk of bleeding.
However, the management of citrate is complex. Optimization is based on citrate flow, blood flow and the amount of calcium reinjected. Frequently the citrate level is sub-dosed.Currently, the fraction of excretion of citrate by the hemodialysis machine is unknown. Knowing this information would allow, if it is important enough, to add an additional parameter of citrate management by adapting the level of dialysis.
The determination of citrate in an extracorporeal circulation circuit has already been performed and has been validated in the literature. We propose to perform the assay on subjects with the same starting parameters, in order to deduce the clearance of citrate.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intensive care dialysis patients (Continuous Venous Hemofiltration with citrate).
排除标准
- 未提供
结局指标
主要结局
Citrate concentration - pre-filter
时间窗: 30 minutes after the start of dialysis
Citrate concentration in a blood sample taken before the dialysis filter
Citrate concentration - post-filter
时间窗: 30 minutes after the start of dialysis
Citrate concentration in a blood sample taken after the dialysis filter
Citrate concentration - dialysate
时间窗: 30 minutes after the start of dialysis
Citrate concentration in a blood sample taken in the dialysate
次要结局
- Weight(Baseline)
- Height(Baseline)
- Sex(Baseline)
- Na (sodium) concentration -pre-filter(30 minutes after the start of dialysis)
- Age(Baseline)
- Apache II score(Baseline)
- SOFA (Sequential Organ Failure Assessment) score(Baseline)
- Glomerular filtration rate (GFR)(Baseline)
- Creatinin level(Baseline)
- Diuresis(Baseline)
- KDIGO classification(Baseline)
- Na (sodium) concentration -post-filter(30 minutes after the start of dialysis)
- Cl (chlorine) concentration - pre-filter(30 minutes after the start of dialysis)
- Cl (chlorine) concentration -post-filter(30 minutes after the start of dialysis)
- K (potassium) concentration - pre-filter(30 minutes after the start of dialysis)
- K (potassium) concentration - post-filter(30 minutes after the start of dialysis)
- Total Ca (calcium) concentration -pre-filter(30 minutes after the start of dialysis)
- Total Ca (calcium) concentration -post-filter(30 minutes after the start of dialysis)
- Total Ca (calcium) concentration -dialysate(30 minutes after the start of dialysis)
- Ionized calcium (Ca2+) concentration -pre-filter(30 minutes after the start of dialysis)
- Ionized calcium (Ca2+) concentration -post-filter(30 minutes after the start of dialysis)
- Ionized calcium (Ca2+) concentration -dialysate(30 minutes after the start of dialysis)
- Mg (magnesium) concentration - pre-filter(30 minutes after the start of dialysis)
- Mg (magnesium) concentration - post-filter(30 minutes after the start of dialysis)
- PO4 (phosphate) concentration - pre-filter(30 minutes after the start of dialysis)
- PO4 (phosphate) concentration - post-filter(30 minutes after the start of dialysis)
- Lactate concentration - pre-filter(30 minutes after the start of dialysis)
- Lactate concentration - post-filter(30 minutes after the start of dialysis)
- Albumin concentration -pre-filter(30 minutes after the start of dialysis)
- Albumin concentration -post-filter(30 minutes after the start of dialysis)
- pH - pre-filter(30 minutes after the start of dialysis)
- pH - post-filter(30 minutes after the start of dialysis)
- Total C-reactive protein (CRP) -pre-filter(30 minutes after the start of dialysis)
- Total C-reactive protein (CRP) -post-filter(30 minutes after the start of dialysis)
- Total C-reactive protein (CRP) -dialysate(30 minutes after the start of dialysis)
- Monomeric C-reactive protein (CRP) -pre-filter(30 minutes after the start of dialysis)
- Monomeric C-reactive protein (CRP) -dialysate(30 minutes after the start of dialysis)
- Monomeric C-reactive protein (CRP) -post-filter(30 minutes after the start of dialysis)
研究者
Dr David DE BELS
Head of intensive care unit
Brugmann University Hospital