Population pharmacokinetic-pharmacodynamic model of general anesthesia for propofol, sufentanil and atracurium, considering the propofol exhaled air concentration and EEG (BIS)
- Conditions
- Patients undergoing elective surgery who have an indication to use arterial blood pressure monitoring.
- Registration Number
- DRKS00017026
- Lead Sponsor
- niversitätsklinikum des Saarlandes
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
Written consent of the patient; Electively operated patients under general anesthesia; The indication due to surgery and / or anesthesia to establish arterial blood pressure monitoring
Exclusion Criteria
Intolerance to propofol, sufentanil or atracurium; Children and adolescents (<18 years of age); Patients undergoing emergency surgery; Drug abuse; Positive HIV test; Positive hepatitis test; Pregnancy; Patients in whom the indication for anesthesia with volatile anesthetics is made; Patients who are not indicated to use arterial blood pressure monitoring; Rejection by the patient
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Model parameters with inter- and intraindividual variability (variance) for compartment volumes, clearances and transfer constants of a population-pharmacokinetic-pharmacodynamic model of general anesthesia for propofol, sufentanil and atracurium taking into account the EEG (bispectral index)
- Secondary Outcome Measures
Name Time Method Investigation of the influence of co-variables on parameters within the pharmacokinetic model.