Fatigue after prophylactic cranial irradiation in stage-I-III small cell lung cancer patients: is there a substrate on functional magnetic resonance imaging of the brain?
Recruiting
- Conditions
- fatigue, prophylactic cranial irradiation, small cell lung cancer, MRIvermoeidheid, profylactische schedelbestraling, kleincellig longcarcinoom, MRI
- Registration Number
- NL-OMON29029
- Lead Sponsor
- AzMPO Box 5800 6202 AZ MaastrichtThe Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 46
Inclusion Criteria
Stage I-III SCLC:
-Age >/= 18 years
Exclusion Criteria
- Prior radiotherapy to the brain
- Claustrophobia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in white matter integrity and bold response after PCI. Differences between SCLC patients and controls for change in white matter integrity and bold response.
- Secondary Outcome Measures
Name Time Method -Relationship between changes in MRI parameters and changes in MVI-20, EORTC c30, EuroQol-5D , HADS and CFQ<br /><br>-Relationship between changes in MRI parameters and changes in IL-6, TNF¦Á, CRP and leukocytes/differential<br /><br>-To evaluate whether there are differences on MRI findings/laboratory findings / questionnaires between SCLC patients treated with PCI, NSCLC patients and healthy controls<br>