Cognitive sequelae of Prophylactic Cranial Irradiation in non-small cell lung cancer patients

• Conditions: cognitive dysfunction; problems with memory; learning and the ability to concentrate; 10029305

• Registration Number: NL-OMON33372
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 170

Inclusion Criteria

- participating in the phase III trial: Prophylactic Cranial Irradiation (PCI) versus observation in radically treated patients with stage III non-small lung cancer: a phase III randomized study ((NVALT 11/DLCRG-02).
- sufficient proficiency in Dutch language
- MRI and not CT scan pre-PCI

Exclusion Criteria

none

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Performance on neuropsychological tests:<br /><br>Rey Auditory Verbal Learning test, short form<br /><br>Trailmaking A and B<br /><br>Controlled Oral Word Association<br /><br>Letter-number sequencing.<br /><br><br /><br>These neuropsychological tests are chosen based on the information of affected<br /><br>functions by PCI, on their reliability and availability of Dutch norms.<br /><br><br /><br>An extra MRI scan</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>