Effect of skin graft with and without phototherapy in the treatment of acral vitiligo

Phase 3

Recruiting

• Conditions: Vitiligo.; Vitiligo

• Registration Number: IRCT20140212016557N9
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Acral vitiligo
18 years of age and higher
Bilateral lesions
Stable vitiligo in the past 6 months
Ability to refer for phototherapy
Minimum size of 1*1 cm
Maximum size of 3*3 cm

Exclusion Criteria

History of keloid
Treatment for vitiligo in the past one month
Poor wound healing
Consumption of anticoagulant drugs
Consumption of immunosuppresant drugs
Pregnancy
Lactation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reversal of normal skin pigment. Timepoint: Months 1, 2, 4, and 6. Method of measurement: Reverse Vitiligo Area Severity Index (VASI), which measures the percentage of pigment reversal.;Vitiligo Extent Score for a Target Area (VESTA). Timepoint: Months 1, 2, 4, and 6. Method of measurement: A formula that considers fully repigmented area, remaining area, and perifollicular repigmentation in the remaining area.

Secondary Outcome Measures

Name	Time	Method
Time of pigment reversal. Timepoint: Months 1, 2, 4, and 6. Method of measurement: Measurement of the numbers of weeks to achieve 50% pigment reversal.;Color match. Timepoint: Months 1, 2, 4, and 6. Method of measurement: Difference of the lesion color with surrounding normal skin color measured by colorimetric device.;Quality of Life. Timepoint: At the beginning and end of treatment. Method of measurement: Vitiligo Quality of Life index (VitiQoL).;Patient satisfaction. Timepoint: At the end of treatment. Method of measurement: Three questions with answers from 0 to 10.