Fluid bolus in suspected sepsis patients with hyperlactatemia: Open-labeled, Randomized controlled trial

Khon Kaen University0 sites224 target enrollmentMay 2, 2023

Overview

Phase: Phase 3
Intervention: Not specified
Conditions: Patients who suspected sepsis with hyperlactatemia in Emergency department of Srinagarind hospital, Khon Kaen university, Khon Kaen Thailand
Sponsor: Khon Kaen University
Enrollment: 224
Status: Not yet recruiting
Last Updated: last year

No summary available.

Registry

who.int

Start Date

May 2, 2023

End Date

June 30, 2024

Last Updated

last year

Study Type

Interventional

Sex

All

Sponsor

•1\) Patients who suspected sepsis: SIRS criteria \> or \= 2 points \+ suspected or confirmed source of infection.
•2\) Hyperlactatemia: Point\-of\-care serum lactate 2\-4 mmol/L from arterial or venous blood gas.
•3\) Ages over or equal 18 years old.

•1\) Congestive heart failure or sign of volume overload or patient who had past history of low ejection fraction (%EF less than 40%) or Functional class IV
•2\) ESRD with and without RRT
•3\) Hypotension due to any cause (SBP \< 90 mmHg or MAP \< 65 mmHg)
•4\) Morbid obesity (BMI \> or \= 40 kg/m2\)
•5\) Pregnancy
•6\) Transferred from another hospital
•7\) Administration of IV fluid before ED arrival
•8\) Refused to participate or DNR
•9\) Suspected type B lactic acidosis e.g., toxin\-induced (metformin, isoniazid, NRTIs), liver failure or thiamine deficiency