TCTR20230502003Not yet recruitingPhase 3
Fluid bolus in suspected sepsis patients with hyperlactatemia: Open-labeled, Randomized controlled trial
Conditions
Trial Snapshot
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- Khon Kaen University
- Enrollment
- 224
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to N/A (No limit) (—)
- Sex
- All
Inclusion Criteria
- •1) Patients who suspected sepsis: SIRS criteria > or = 2 points + suspected or confirmed source of infection.
- •2) Hyperlactatemia: Point-of-care serum lactate 2-4 mmol/L from arterial or venous blood gas.
- •3) Ages over or equal 18 years old.
Exclusion Criteria
- •1) Congestive heart failure or sign of volume overload or patient who had past history of low ejection fraction (%EF less than 40%) or Functional class IV
- •2) ESRD with and without RRT
- •3) Hypotension due to any cause (SBP < 90 mmHg or MAP < 65 mmHg)
- •4) Morbid obesity (BMI > or = 40 kg/m2)
- •5) Pregnancy
- •6) Transferred from another hospital
- •7) Administration of IV fluid before ED arrival
- •8) Refused to participate or DNR
- •9) Suspected type B lactic acidosis e.g., toxin-induced (metformin, isoniazid, NRTIs), liver failure or thiamine deficiency
Investigators
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