Optical Coherence Tomography to visualize neuropathology in Alzheimer's disease

Completed

Conditions: Alzheimer's disease and dementia
10042258

Registration Number: NL-OMON45755

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

- Study cases: patients with AD fulfilling the clinical criteria, a MMSE-score of at least 17/30 and proven to be amyloid positive by either decreased CSF A* or a positive amyloid PET scan.
- Controls: patients with subjective memory complaints visiting the Alzheimer center, without diagnosis of AD or other neurodegenerative disease, proven to be amyloid negative by either normal CSF A* or negative amyloid PET scan.

Exclusion Criteria

- Subjects with neuro-opthalmological conditions which may interfere with the OCT data
- Subjects with progressive dementia, with an MMSE below 17/30 and/or incapacitated and not capable to give informed consent.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- OCT: thickness of the individual retinal layers, including the choroid, at<br /><br>the macular region and optic disc<br /><br>- PS-OCT: presence (and number) of amyloid plaques, thickness and change in<br /><br>birefringence of RNFL<br /><br>- Angio-OCT: changes in vessel density around the optic nerve head</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Relate the amount of visualized A*-plaques in the retina of AD patients to<br /><br>other available AD biomarkers (i.e. hippocampal atrophy, CSF biomarkers and<br /><br>amyloid PET scan).<br /><br>- Compare findings of standard OCT with available biomarkers (i.e. hippocampal<br /><br>atrophy, CSF biomarkers and amyloid PET scan)<br /><br>- Compare findings in vessel density around the optic nerve head to<br /><br>existing vascular markers (scores on MRI) </p><br>