ISRCTN15839026已完成4 期
A pilot, randomised, unlinded, feasibility, safety and biochemical and physiological efficacy study of 20% versus 5% human albumin solution for fluid bolus therapy in critically ill adults
Central Manchester University Hoapitals NHS Foundation Trust0 个研究点目标入组 321 人开始时间: 2017年12月19日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 321
研究概览
简要总结
2018 results in https://www.ncbi.nlm.nih.gov/pubmed/30343313 (added 11/04/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Admitted to the Department of Intensive Care, Austin Hospital for less than 24 hours or to the Intensive and Critical Care Department of the Flinders Medical Centre for less than 24 hours
- •2. Age 18 years or greater
- •3. Need for fluid bolus as determined by the treating clinician
- •4. Presence of one or more of the following physiological states: systolic BP <90 mmHg, or MAP <65 mmHg, or increasing need for vasopressor drug infusion or pulse pressure variation >12 % or stroke volume variation >12%, or Cardiac index <2.2 L/min/m2 or heart rate >100 or urinary output <20 ml/hr or either rising lactate levels or lactate levels >2 mmol/L or capillary refill time >3 seconds or central venous pressure <8 mmHg
排除标准
- •1. Confirmed or suspected pregnancy
- •2. Patients with traumatic brain injury
- •3. Active bleeding
- •4. Haemoglobin level <70 g/L
- •5. People who refuse blood products
- •6. Patients in whom death is considered imminent (within 24 hours)
研究者
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