Intrauterine Infusion of Platelet-rich Plasma Infusion Before Thawed Embryo Transfer in Repeated Implantation Failure: A Randomized Controlled Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Endometrial thickness
研究概览
简要总结
All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion
详细描述
Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups:
Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11
Group II: Not receiving platelet rich plasma (PRP)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients age 20-35 years
- •Patients with previous implantation failure
- •Patients with thin endometrium<7 mm
排除标准
- •Patients older than 40 years
- •Patients with fresh embryo transfer
- •Patients with abnormal uterine cavity septate, or bicornuate uterus
- •Patients with abnormal male factor or tubal factor
- •Patients with abnormal embryos grade B or C.
- •Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis
研究组 & 干预措施
PRP group
These patients will receive platelet rich plasma intrauterine infusion at day 11
干预措施: Platelet rich plasma intrauterine infusion (Biological)
Control group
These patients will receive intrauterine normal saline infusion at day 11
干预措施: Normal saline (Biological)
结局指标
主要结局
Endometrial thickness
时间窗: 8 days
The increase in endometrial thickness at day of ET
Pregnancy rate
时间窗: 15 days
Number of cases who got pregnant
次要结局
未报告次要终点
研究者
Ayman S Dawood, MD
Lecturer
Tanta University