For Increase in Endometrial Thickness in Women With Thin Endometrium undergoing Infertility Treatment use of Intrauterine Infusion Of Autologous Platelet Rich Plasma (PRP) and Granulocyte Colony Stimulating Factor (G-CSF)
- Conditions
- Health Condition 1: O998- Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
- Registration Number
- CTRI/2024/03/064601
- Lead Sponsor
- Datta megha institute of higher education and research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
women aged 18 to 45 years, thin endometrium less than 7 mm on the day of HCG injection, no contraindications for Platelet rich plasma (PRP) and Granulocyte colony stimulating factor(G-CSF) treatment, Women with a normal transvaginal ultrasound and no evidence of a clinically significant abnormality in the uterus or adnexa, Negative CBNAAT, negative AFB staining & negative TBPCR for genital tuberculosis.
patients with a body mass index more than 30 kg/m2, Positive history of intrauterine synechiae, repeated curettage, endometrial injury, Distorted endometrium cavity, submucosal fibroids, endometrial polyps, severe endometriosis, adenomyosis, pelvic cancer and uterine anomalies, chromosomal abnormalities in couples, patients with abnormal liver and kidney function, abnormal thyroid function, immune disorders, hematological disorders;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method expansion of endometrial thickness (EMT)Timepoint: AT BASELINE, AFTER 10 DAYS, AFTER 12 DAYS, AFTER 14 DAYS , AFTER 16 DAYS
- Secondary Outcome Measures
Name Time Method positive beta-hCG level <br/ ><br>? implantation rate (IR), <br/ ><br>? positive urine pregnancy test <br/ ><br>? clinical pregnancy rate (CPR) by confirmation of Gestational sac with cardiac activity <br/ ><br>in Trans-vaginal sonography (TVS) <br/ ><br>? live birth rate (LBR) (if possible within study periodTimepoint: 2 year