Role of autologous Platelet rich plasma in infertile females.
- Conditions
- Health Condition 1: - Health Condition 2: N979- Female infertility, unspecified
- Registration Number
- CTRI/2021/05/033764
- Lead Sponsor
- vmmc and safdarjung hospital delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
1. Infertile female between 21-37 years.
2. Persistent thin endometrial thickness <=6 mm on >=1 cycle in previous cycle even after conventional treatment with estradiol valearate.
3. HB >11 gm% and platelets >1.5 lakhs
1.History of symptoms of platelet dysfunction such as easy bruisability, frequent nose-bleeds, heavy menstrual bleeding, bleeding gums or excessive bleeding during dental procedures.
2.Blood borne disease like Hepatitis B, Hepatitis C, Syphilis, HIV.
3.NSAIDs intake in 10 days before the procedure
4.Pt on anticoagulant therapy
5.Severe Male factor for infertility
6.Tubal factor for infertility
7.WHO class 1 or 3 ovulatory dysfunction
8.Mullerian abnormality
9.Ashermann Syndrome
10.Moderate /severe endometriosis
11.Active vaginal/cervix infection/pelvic inflammatory disease.
12.Any significant co-morbidity/ psychiatric disorder which compromise or interfere with consent giving/study participation/ follow up or interpretation of study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary Outcome <br/ ><br>1)Change in endometrium thickness. <br/ ><br>2)change in endometrium vascularity <br/ ><br>Timepoint: 36-40 hours post PRP instillation
- Secondary Outcome Measures
Name Time Method Secondary outcome <br/ ><br>1)positive pregnancy rate <br/ ><br>2).clinical pregnancy rate <br/ ><br>Timepoint: <br/ ><br>1)positive pregnancy rate-14 DAYS after intrauterine insemination by urine pregnancy test. <br/ ><br>2)clinical pregnancy rate-28 days after intrauterine <br/ ><br>insemination by transvaginal ultrasound. <br/ ><br>