To study the effect of intrauterine Platelet Rich Plasma therapy on pregnancy rates in unexplained infertility
Phase 3
- Conditions
- Health Condition 1: N979- Female infertility, unspecified
- Registration Number
- CTRI/2024/01/061002
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Diagnosed case of Unexplained infertility (documented ovulation, at least unilateral tubal patency, normal uterine cavity and normal semen analysis).
- BMI: 19-25 Kg/m2
Exclusion Criteria
a) Patient on any hormonal therapy or NSAID
b) Female with the diagnosis of hematological disorder and autoimmune disorder.
c) Females with chronic medical disorder such as diabetes, hypertension and tuberculosis.
d) Presence of active infection such Pelvic inflammatory diseases, vaginal or cervical infection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a) Comparison of Clinical pregnancy rate with and without PRP therapy in IUI in unexplained infertility. <br/ ><br>b) Comparison of endometrial receptivity with and without PRP therapy in IUI in unexplained infertility.Timepoint: a) 15 days after IUI – UPT will be done <br/ ><br>b) 10-15 days after missed period- TVS for cardiac activity or gestational sac will be done to confirm clinical pregnancy <br/ ><br>c) Endometrial receptivity scoring will be done on the day of IUI, 2 days after IUI, and 4 days after IUI
- Secondary Outcome Measures
Name Time Method a) Comparison of luteal phase S. EGF levels with or without PRP therapy in unexplained infertility <br/ ><br>b) Correlation of endometrial receptivity with clinical pregnancy rates <br/ ><br>c) Side effects of PRP therapy in the studyTimepoint: Serum EGF levels after 4 days of IUI