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临床试验/NCT01970839
NCT01970839已完成不适用

Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study

Duke University2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2014年11月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
10
试验地点
2
主要终点
Changes in sensory nerve conduction

研究概览

简要总结

There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application. There is some scientific evidence from animal studies demonstrating that prolonged tourniquet application can result in lack of oxygen supply to nerves, and subsequent nerve damage resulting in chronic pain. This theory has not been proven in humans. In this study the investigators will indirectly assess the evidence for abnormalities caused by tourniquet application on subjects' nerves using well established devices to determine the function of these nerves.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy adults
  • Over 18 years of age

排除标准

  • Neurological disease
  • Diabetes mellitus
  • History of nerve injury
  • Chronic pain
  • Alcoholism
  • Blood pressure measurements greater than 140/80 and infection in the monitored area

结局指标

主要结局

Changes in sensory nerve conduction

时间窗: baseline, 5 minutes

Changes in oxyneurogram index

时间窗: baseline, 5 minutes

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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