Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study
- Conditions
- Sensory Nerve ConductionOxyneurogram Index
- Interventions
- Device: tourniquet, sensory nerve conduction abnormality
- Registration Number
- NCT01970839
- Lead Sponsor
- Duke University
- Brief Summary
There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application. There is some scientific evidence from animal studies demonstrating that prolonged tourniquet application can result in lack of oxygen supply to nerves, and subsequent nerve damage resulting in chronic pain. This theory has not been proven in humans. In this study the investigators will indirectly assess the evidence for abnormalities caused by tourniquet application on subjects' nerves using well established devices to determine the function of these nerves.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Healthy adults
- Over 18 years of age
- Neurological disease
- Diabetes mellitus
- History of nerve injury
- Chronic pain
- Alcoholism
- Blood pressure measurements greater than 140/80 and infection in the monitored area
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Tourniquet, pain, nerve injury, sensory nerve function tourniquet, sensory nerve conduction abnormality -
- Primary Outcome Measures
Name Time Method Changes in sensory nerve conduction baseline, 5 minutes Changes in oxyneurogram index baseline, 5 minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Duke University Medical Center
🇺🇸Durham, North Carolina, United States