to evaluate and compare 2% Lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateralmandibular extractions

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/04/052054
• Lead Sponsor: Dr Piyush Lunkad

Brief Summary

- Local anaesthesia is a medium to control pain during the dental extraction.

- The use of hyaluronidase in local anesthesia is a common practice in ophthalmological surgery.

- When hyaluronidase was incorporated adequate block would be established with smaller volumes of anesthetic solution.

- The role of hyaluronidase  is that it increases the diffusablitiy of the local anesthetic through tissues so as to reach it to nerve, therefore when it is used in conjugation with LA solution, it might fasten onset of anesthetic effect.

- By administration of hyaluronidase the interval between completion of block and the establishment of analgesia is markedly reduced.

- The spreading effects appears to be increased by epinephrine

- .In this study we compare and evaluated the efficacy of 2 % lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions. We also evaluated the onset, duration and need of any supplementary anaesthesia in both the groups. In this study we compare and evaluated the efficacy of 2 % lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions. We also evaluated the onset, duration and need of any supplementary anaesthesia in both the groups.

- In this study we compare and evaluated the efficacy of 2 % lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions. We also evaluated the onset, duration and need of any supplementary anaesthesia in both the groups.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-04-26
• Study Start: 2023-05-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

Patients who are 18 years and above Patients requiring bilateral mandibular teeth extraction Patients who are willing to participate in the study .

Exclusion Criteria

Patients with history of systemic disease [ uncontrolled diabetes , uncontrolled hypertension, radiotherapy and bleeding disorder, mental disorder ] Patients with any local infection Patients with pre-operative pain Patient allergic to local anesthesia Patients allergic to hyaluronidase Root pieces with periapical pathology likecyst, tumor etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the pain perception	immediately postoperatively

Secondary Outcome Measures

Name	Time	Method
pain	immediate post operative

Trial Locations

Locations (1)

Dr D Y Patil Dental College and Hospital; 🇮🇳 Pune, MAHARASHTRA, India

Dr D Y Patil Dental College and Hospital

🇮🇳Pune, MAHARASHTRA, India

Dr piyush Lunkad

Principal investigator

9822415680

piyush.lunkad12@gmail.com