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Neural Correlates of Tactile Prediction

Not Applicable
Conditions
Premature Birth
Neurodevelopmental Disorders
Registration Number
NCT04844853
Lead Sponsor
University Hospital, Caen
Brief Summary

This project aims to measure repetition suppression and tactile prediction using high-resolution electroencephalography in preschoolers, in order to describe the responses as a function of age, gestational age of birth and the presence of a neurodevelopmental disorder. We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. We will perform several behavioral evaluations to analyze the results in view of the quality of development.

Detailed Description

We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. Children will be recruited from local schools and institutions. Birth will be considered premature if children were born before 36 weeks of gestational age. Children will be considered as having neurodevelopmental disorder if they receive medical and/or paramedical care at the time of measurement for neurodevelopmental disorder, including autism spectrum disorder, attention deficit with or without hyperactivity, tics, learning disorders, but all participants must be attending school at the time of measurement.

Children will come to the lab for a 2 hours session with their parents, during which they will undergo movement, attention and executive functions evaluations. Parents will fill out questionnaires evaluating their child's executive functioning and sensory profile in home/everyday settings. Children will then be equipped with 128-channels electroencephalography and proposed two tests : a modified attention network task and a tactile prediction task.

We will calculate correlations between evoked potential amplitudes during the tactile prediction trials and inhibitory conflict trials. Results will be analysed in the light of age, gestational age at birth, ecological and psychometric evaluations, and neurodevelopmental status.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
100
Inclusion Criteria
  • Age 24 to 35 or 72 to 83 months
  • Born prematurely or term, with or without neurodevelopmental disorders (see arms)
  • Parental informed consent
  • Attending school
Exclusion Criteria
  • Severe IQ deficit or language impairment
  • Psychotropic medication

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Tactile prediction at 66 years

Difference of amplitude between baseline and omission segment

Tactile prediction at 22 years

Difference of amplitude between baseline and omission segment

Repetition suppression at 22 years

Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence

Repetition suppression at 66 years

Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Comete U1075 Inserm Unicaen

🇫🇷

Caen, France

Comete U1075 Inserm Unicaen
🇫🇷Caen, France
Nadege Roche-Labarbe, PhD
Contact

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