Impact of Washed Transfusions in Adult Patients With Acute Myeloid or Lymphoid Leukemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Survial Rate at 30 Days
研究概览
简要总结
The purpose of this study is to determine whether a novel standard of care protocol, washing red cell and platelet transfusions for younger patients with acute leukemia, has yielded improved clinical outcomes at Strong Memorial Hospital (Rochester, New York, USA). This standard of care was implemented based upon an earlier randomized trial (BMC Blood Disorders. 2004 Dec 10;4(1):6) The comparator will be historical controls from the medical literature.
详细描述
The purpose of this study is to determine whether a novel standard of care protocol, washing red cell and platelet transfusions for younger patients with acute leukemia, has yielded improved clinical outcomes at Strong Memorial Hospital (Rochester, New York, USA). This standard of care was implemented based upon an earlier randomized trial (BMC Blood Disorders. 2004 Dec 10;4(1):6) The comparator will be historical controls from the medical literature. Key outcomes will be treatment related mortality (deaths at 30, 60 and 100 days) and three year survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •previously untreated patients with a diagnosis of acute leukemia between the ages of 0 and 50 (AML) and 18 and 50 (ALL)
排除标准
- •all other patients
结局指标
主要结局
Survial Rate at 30 Days
时间窗: 30 days
The percentage of patients who were alive at 30 days after transfusion.
Survial Rate at 60 Days
时间窗: 60 days
The percentage of patients who were alive at 60 days after transfusion.
Survial Rate at 5 Years
时间窗: 5 years
The percentage of patients who were alive at 5 years after transfusion.
Survial Rate at 100 Days
时间窗: 100 days
The percentage of patients who were alive at 100 days after transfusion.
次要结局
未报告次要终点
研究者
Neil Blumberg
Professor
University of Rochester