Impact of Washed Transfusions in Adult Patients With Acute Myeloid or Lymphoid Leukemia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Leukemia, Myeloid, Acute
- Sponsor
- University of Rochester
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Survial Rate at 30 Days
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine whether a novel standard of care protocol, washing red cell and platelet transfusions for younger patients with acute leukemia, has yielded improved clinical outcomes at Strong Memorial Hospital (Rochester, New York, USA). This standard of care was implemented based upon an earlier randomized trial (BMC Blood Disorders. 2004 Dec 10;4(1):6) The comparator will be historical controls from the medical literature.
Detailed Description
The purpose of this study is to determine whether a novel standard of care protocol, washing red cell and platelet transfusions for younger patients with acute leukemia, has yielded improved clinical outcomes at Strong Memorial Hospital (Rochester, New York, USA). This standard of care was implemented based upon an earlier randomized trial (BMC Blood Disorders. 2004 Dec 10;4(1):6) The comparator will be historical controls from the medical literature. Key outcomes will be treatment related mortality (deaths at 30, 60 and 100 days) and three year survival.
Investigators
Neil Blumberg
Professor
University of Rochester
Eligibility Criteria
Inclusion Criteria
- •previously untreated patients with a diagnosis of acute leukemia between the ages of 0 and 50 (AML) and 18 and 50 (ALL)
Exclusion Criteria
- •all other patients
Outcomes
Primary Outcomes
Survial Rate at 30 Days
Time Frame: 30 days
The percentage of patients who were alive at 30 days after transfusion.
Survial Rate at 60 Days
Time Frame: 60 days
The percentage of patients who were alive at 60 days after transfusion.
Survial Rate at 5 Years
Time Frame: 5 years
The percentage of patients who were alive at 5 years after transfusion.
Survial Rate at 100 Days
Time Frame: 100 days
The percentage of patients who were alive at 100 days after transfusion.