Serum Lactate in Acute Mesenteric Ischemia

Completed

• Conditions: Mesenteric Ischemia

• Registration Number: NCT04671979
• Lead Sponsor: Universidad del Rosario

Brief Summary

Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization.

Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-02
• Primary Completion: 2020-06-30
• Study Completion: 2020-06-30
• Status Verified: 2020-12
• Study First Submitted: 2020-12-03
• Study First Submitted QC: 2020-12-11
• Last Update Submitted: 2020-12-11
• Study First Posted: 2020-12-17
• Last Update Posted: 2020-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Older than 18 years of age
• Required urgent laparotomy with a postoperative diagnosis of acute mesenteric ischemia
• Attended the private academic hospital, between 2012 and 2018
• Had a registered serum lactate dehydrogenase at admission

Exclusion Criteria

• Secondary causes of AMI
• Chronic intestinal ischemic
• Patient records with no description of the serum lactate dehydrogenase or extension of intestinal necrosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bowel necrosis length in cm	30 days
Serum Lactate in mmol/l	30 days
Percentage of patients that died between 30 postsurgical days, %	30 days

Secondary Outcome Measures

Name	Time	Method
Cut value of lactate levels as a predictor of mortality, in mmol/l	30 days	A receiver operating characteristics curve

Trial Locations

Locations (1)

Andres Isaza Restrepo; 🇨🇴 Bogotá, Cundinamarca, Colombia