Role of intestinal fatty acid binding protein (I-FABP) in diagnosing acute mesenteric ischemia.
- Conditions
- mesenteric ischemia
- Registration Number
- NL-OMON26895
- Lead Sponsor
- Catharina hospital Eindhoven
- Brief Summary
1. Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med 2004;164:1054-62.PMID 15159262.<br> 2. Kassahun WT, Schulz T, Richter O, Hauss J. Unchanged high mortality rates from acute occlusive intestinal ischemia: six year review. Langenbecks Arch Surg 2008;393:163-71.PMID 18172675.<br> 3. Sise MJ. Mesenteric ischemia: the whole spectrum. Scand J Surg;99:106-10.PMID 20679047 4. Thuijls G, van Wijck K, Grootjans J, Derikx JP, van Bijnen AA, Heineman E, Dejong CH, Buurman WA, Poeze M. Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins. Ann Surg;253:303-8.PMID 21245670.<br> 5. Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology;256:93-101.PMID 20574087.<br> 6. Thuijls G, Derikx JP, van Wijck K, Zimmermann LJ, Degraeuwe PL, Mulder TL, Van der Zee DC, Brouwers HA, Verhoeven BH, van Heurn LW, Kramer BW, Buurman WA, Heineman E. Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann Surg;251:1174-80.PMID 20485148.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 263
1. Age ≥ 18 jaar;
2. Suspection of acute mesenteric ischemia;
Previous abdominal surgery within 1 week of presentation.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method I-FABP concentraties in blood and urine compared with result of CT-angiography and surgery.
- Secondary Outcome Measures
Name Time Method 1. Mortality;<br /><br>2. Negative laparotomy;<br /><br>3. Other diagnosis.